2-Pyridinecarboxylic acid, 6,6'-dithiobis- | 38123-45-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Pyridinecarboxylic acid, 6,6'-dithiobis-
• 英文别名: 6-[(6-carboxypyridin-2-yl)disulfanyl]pyridine-2-carboxylic acid
• CAS: 38123-45-4
• 化学式: C₁₂H₈N₂O₄S₂
• 分子量: 308.3
• InChiKey: XAVCTYVSLHKLOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  151
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• METHOD OF IMMUNOMODULATION USING THIONE-FORMING DISULFIDES
  申请人：The GRASSETTI Family Trust

  公开号：EP1383499B1

  公开（公告）日：2013-03-06
• Inhibition of IL-1 Induced Inflammation
  申请人：THIOLAB, LLC.

  公开号：US20220193060A1

  公开（公告）日：2022-06-23

  This invention provides methods of treatment for a variety of inflammation pathologies using thione-forming disulfides (TFDs). The treatments are particularly effective in the context of inflammations primarily due to excessive activity of innate immune system components, macrophage activity and inflammation arising from excessive production of IL-1. TFD inhibition of both IL-1 and IL-6 can reduce the detrimental effects of the cytokine storms known to increase morbidity and mortality caused by certain infections, such as COVID-19 viral pneumonia.
• US4152439A
  申请人：——

  公开号：US4152439A

  公开（公告）日：1979-05-01
• US8163776B2
  申请人：——

  公开号：US8163776B2

  公开（公告）日：2012-04-24