5-羟基-6-甲基吡啶-3,4-二甲醇磷酸酯 | 1142-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-羟基-6-甲基吡啶-3,4-二甲醇磷酸酯
• 中文别名: 5-羟基-6-甲基吡啶-3,4-磷酸二甲醇
• 英文名称: 5-Hydroxy-6-methylpyridine-3,4-dimethanol phosphate
• 英文别名: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;phosphoric acid
• CAS: 1142-43-4
• 化学式: C8H14NO7P
• 分子量: 267.17
• InChiKey: IPGWPDHPOQYBMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.85
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  151
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• [EN] NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE<br/>[FR] NOUVELLES OPTIONS SYNTHÉTIQUES POUR LA FABRICATION DE (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL) PHÉNYL]-6-OXO-1(6H)-PYRIMIDINYL}1-(DIFLUOROMÉTHYL)-6-MÉTHYL-1,4,7,8,9,10-HEXAHYDRO-11,15- (METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTÉTRADECIN-5 (6H)-ONE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2020210613A1

  公开（公告）日：2020-10-15

  Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

  为合成化合物（I）的关键中间体提供了高效的方法，这些方法具有广泛的适用性，并且可以提供具有各种取代基团的选定组分。
• Transaminase reactions
  申请人：Codexis, Inc.

  公开号：US10138503B2

  公开（公告）日：2018-11-27

  The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

  本公开涉及使用转氨酶多肽在合成手性胺类化合物中从原性酮中合成手性胺的方法。
• [EN] NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES<br/>[FR] NOUVEAU PROCÉDÉ POUR DES INTERMÉDIAIRES DE SACUBITRIL PRÉCOCES
  申请人：NOVARTIS AG

  公开号：WO2018116203A1

  公开（公告）日：2018-06-28

  The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.

  这项发明涉及一种新的对映选择性工艺，用于生产用于制造NEP抑制剂或其前药的有用中间体，特别是包含γ-氨基-δ-联苯基-α-甲基烷酸或酸酯骨架的NEP抑制剂。
• [EN] CHEMICAL PROCESS FOR PREPARING SPIROINDOLONES AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ CHIMIQUE POUR LA PRÉPARATION DE SPIROINDOLONES ET INTERMÉDIAIRES CORRESPONDANTS
  申请人：NOVARTIS AG

  公开号：WO2013139987A1

  公开（公告）日：2013-09-26

  The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1'R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3, 4-b]indol]-2-one and salts and hydrates and solvates thereof.

  本发明涉及用于制造螺环吲哚酮类化合物的过程和中间体，例如（1'R,3'S）-5,7'-二氯-6'-氟-3'-甲基-2',3',4',9'-四氢螺环[吲哚-3,1'-哌啶[3,4-b]吲哚]-2-酮及其盐、水合物和溶剂化合物。
• COMPOSITIONS CONTAINING SUCRALOSE AND APPLICATION THEREOF
  申请人：Inoue Maki

  公开号：US20120121734A1

  公开（公告）日：2012-05-17

  Novel utilization of sucralose which is a high intense sweetener. Compositions containing sucralose including: sweetening compositions having excellent sweetness qualities based on the characteristics of sucralose; foods with a masked unpleasant smell and unpleasant taste; performance food compositions (viscous food compositions, gel food compositions, emulsified food compositions); foods with improved flavors; preservatives and foods with improved quality of taste; and flavor compositions with improved flavors. Novel utilization of sucralose as a sweetener improver, a masking agent for unpleasant smell/unpleasant taste, a flavor improver, a function improver (viscosity, gelling properties, emulsification properties), a taste characteristic improver, and a flavor improver/enhancer.

  对蔗糖烯糖醇的新型利用，这是一种高强度甜味剂。包含蔗糖烯糖醇的组合物包括：基于蔗糖烯糖醇特性具有出色甜味品质的甜味组合物；具有掩盖难闻气味和难吃味道的食品；性能食品组合物（粘性食品组合物、凝胶食品组合物、乳化食品组合物）；具有改善口味的食品；具有改善口味质量的防腐剂和食品；以及具有改善口味的风味组合物。对蔗糖烯糖醇作为甜味改进剂、掩盖剂（用于难闻气味/难吃味道）、口味改进剂、功能改进剂（粘度、凝胶性能、乳化性能）、口味特性改进剂以及风味改进剂/增强剂的新型利用。