propanethial | 16696-81-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代羰基化合物
• 英文名称: propanethial
• 英文别名: Propanthial；thiopropanal；thiopropionaldehyde；Thiopropionaldehyd
• CAS: 16696-81-4
• 化学式: C₃H₆S
• 分子量: 74.1466
• InChiKey: UXBLKIPIXRLLBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  4
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  propanethial 、 盐酸 以76%的产率得到
  参考文献：
  名称：

  DUBS P.; STUESSI R., HELV. CHIM. ACTA, 1978 61, NO 7, 2351-2359

  摘要：

  DOI：

文献信息

• Uses of methyl(methylthioalkyl)-1,3-dithiolanes in augmenting or
  申请人：International Flavors & Fragrances Inc.

  公开号：US04472446A1

  公开（公告）日：1984-09-18

  Described is the genus of methyl(methylthioalkyl)-1,3-dithiolanes defined according to the structure: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents methyl or hydrogen with the proviso that at least one of R.sub.1 and R.sub.2 is methyl; and wherein m represents an integer of 1 or 2 and uses of such methyl(methylthioalkyl)-1,3-dithiolanes in augmenting or enhancing the aroma or taste of foodstuffs.

  本发明涉及一种甲基（甲硫基烷基）-1,3-二硫杂环的属，其定义如下：##STR1## 其中R.sub.1和R.sub.2相同或不同，每个代表甲基或氢，但至少其中之一为甲基；m表示1或2。本发明还涉及使用这种甲基（甲硫基烷基）-1,3-二硫杂环增强或提高食品的香气或味道。
• Synthesis of indoles from anilines and intermediates therein
  申请人：The Ohio State University Research Foundation

  公开号：US03992392A1

  公开（公告）日：1976-11-16

  Preparing indoles and intermediates therefor by reacting an N-haloaniline with a .beta.-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the .beta.-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an .alpha.-ethyl-.beta. -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

  通过将N-卤代苯胺与β-羰基烃基硫醚反应形成氮硫杂环卤化铵，再将氮硫杂环卤化铵与强碱反应形成硫醚吲哚衍生物，然后还原硫醚吲哚，例如使用Raney镍，形成吲哚化合物。当使用β-羰基烃基硫醚的缩醛或缩酮时，处理氮硫杂环盐，然后用酸处理形成硫醚吲哚衍生物。当使用α-乙基-β-羰基烃基硫醚时，生成的偶氮硫杂环盐与强碱反应形成硫醚吲哚啉衍生物，经Raney镍或复合金属氢化物还原后得到3-取代吲哚。苯胺可以是氨基吡啶，以在过程中形成氮杂吲哚化合物。可以从各自的反应混合物中分离和回收氮硫杂环盐和硫醚吲哚或硫醚吲哚啉衍生物。硫醚吲哚和硫醚吲哚啉衍生物是制备不含硫醚基的吲哚的中间体。吲哚是已知的化合物，具有广泛的用途，例如用于制造香料、染料、氨基酸、药物、农业化学品等。
• Methyl(methylthioalkyl)-1,3-dithiolanes
  申请人：International Flavors & Fragrances Inc.

  公开号：US04515967A1

  公开（公告）日：1985-05-07

  Described is the genus of methyl(methylthioalkyl)-1,3-dithiolanes defined according to the structure: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents methyl or hydrogen with the proviso that at least one of R.sub.1 and R.sub.2 is methyl; and wherein m represents an integer of 1 or 2 and uses of such methyl(methylthioalkyl)-1,3-dithiolanes in augmenting or enhancing the aroma or taste of foodstuffs.

  本发明涉及一类甲基（甲硫烷基）-1,3-二硫杂环己烷属，其结构定义如下：##STR1## 其中R.sub.1和R.sub.2相同或不同，每个代表甲基或氢，但至少其中之一为甲基；m表示1或2。本发明还涉及将这种甲基（甲硫烷基）-1,3-二硫杂环己烷用于增强或提高食品的香味或味道。
• Alpha-methylthio-alpha-(2-aminophenyl) acetaldehyde diloweralkyl acetals
  申请人：The Ohio State University Research Foundation

  公开号：US04101583A1

  公开（公告）日：1978-07-18

  Preparing indoles and intermediates therefor by reacting an N-haloaniline with a .beta.-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the .beta.-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an .alpha.-ethyl-.beta.-carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like. The present application is particularly directed to alpha-methylthio-alpha-(2-aminophenyl) acetaldehyde diloweralkyl acetals.

  通过将N-卤代苯胺与β-羰基烃基硫化物反应形成氮杂硫鎓卤化物，再将氮杂硫鎓卤化物与强碱反应形成硫醚吲哚衍生物，然后还原硫醚吲哚，例如使用Raney镍，形成吲哚化合物。当使用β-羰基烃基硫化物的缩醛或缩酮时，将处理氮杂硫鎓盐与碱，然后与酸反应形成硫醚吲哚衍生物。当使用α-乙基-β-羰基烃基硫化物时，所得的氮杂硫鎓盐与强碱反应形成硫醚吲哚啉衍生物，经过Raney镍或复合金属氢化物还原后可以得到3-取代吲哚。苯胺可以是氨基吡啶，以形成氮杂吲哚化合物。可以从各自的反应混合物中分离和回收硫醚吲哚或硫醚吲哚啉衍生物。硫醚吲哚和硫醚吲哚啉衍生物是制备不含硫醚基的吲哚的中间体。吲哚是已知的化合物，具有广泛的用途，例如制造香料、染料、氨基酸、制药、农业化学品等。本申请特别针对α-甲基硫基-α-(2-氨基苯基)乙醛二低烷基缩醛。
• Certain N-phenyl or N-pyridyl aza sulfonium salts
  申请人：The Ohio State University Research Foundation

  公开号：US04067875A1

  公开（公告）日：1978-01-10

  Preparing indoles and intermediates therefor by reacting an N-haloaniline with a .beta.-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the .beta.-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an .alpha.-ethyl-.beta.-carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

  通过将N-卤代苯胺与β-羰基烃基硫醚反应形成氮杂硫鎓卤化物，然后用强碱反应氮杂硫鎓卤化物形成硫醚吲哚衍生物，再将硫醚吲哚还原，例如使用Raney镍，形成吲哚化合物。当使用β-羰基烃基硫醚的缩醛或缩酮时，处理氮杂硫鎓盐与碱，然后与酸反应形成硫醚吲哚衍生物。当使用α-乙基-β-羰基烃基硫醚时，所得的氮杂硫鎓盐与强碱反应形成硫醚吲哚啉衍生物，经过Raney镍或复合金属氢化物还原后得到3-取代吲哚。苯胺可以是氨基吡啶，以在过程中形成氮杂吲哚化合物。氮杂硫鎓盐和硫醚吲哚或硫醚吲哚啉衍生物可以从各自的反应混合物中分离和回收。硫醚吲哚和硫醚吲哚啉衍生物是制造不含硫醚基的吲哚的中间体。吲哚是已知的化合物，具有广泛的用途，例如用于制造香料、染料、氨基酸、制药、农药等。