N(6)-Endonorbornan-2-yl-9-methyladenine | 141696-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N(6)-Endonorbornan-2-yl-9-methyladenine
• 英文别名: N-[(1S,2R,4R)-2-bicyclo[2.2.1]heptanyl]-9-methylpurin-6-amine
• CAS: 141696-90-4
• 化学式: C₁₃H₁₇N₅
• 分子量: 243.31
• InChiKey: MTQYIGCUBBMQCJ-KXUCPTDWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  endo-2-aminonorbornane 、 6-氯-9-甲基嘌呤 以75的产率得到N(6)-Endonorbornan-2-yl-9-methyladenine
  参考文献：
  名称：

  [EN] ARRANGEMENT FOR CONTROLLING ROCK DRILLING
  [FR] DISPOSITIF DE COMMANDE POUR LE FORAGE DE ROCHE

  摘要：

  该发明涉及一种用于控制液压岩钻装置的装置。该适配器包括一个压力比阀（18；18'），用于调节通向冲击装置和/或其他执行器（如杆稳定器（28））的压力通道与通向进给机构的压力通道之间的压力关系。压力比阀（18；18'）被设置为在正常钻探范围内保持执行器和进给机构之间的压力关系恒定。

  公开号：

  WO2000008303A1

文献信息

• [EN] ARRANGEMENT FOR CONTROLLING ROCK DRILLING<br/>[FR] DISPOSITIF DE COMMANDE POUR LE FORAGE DE ROCHE
  申请人：SANDVIK TAMROCK OY

  公开号：WO2000008303A1

  公开（公告）日：2000-02-17

  The invention concerns an arrangement for controlling a hydraulic rock drilling device. The adaptation includes a pressure ratio valve (18; 18') that is used for adjusting the relation between the pressures in the pressure channel leading to the percussion device and/or other actuator, such as a shank stabilizer (28), and the pressure channel leading to the feed mechanism. The pressure ratio valve (18; 18') is arranged to keep the relation between the pressures of the actuator and the feed mechanism constant over the normal drilling range.

  该发明涉及一种用于控制液压岩钻装置的装置。该适配器包括一个压力比阀（18；18'），用于调节通向冲击装置和/或其他执行器（如杆稳定器（28））的压力通道与通向进给机构的压力通道之间的压力关系。压力比阀（18；18'）被设置为在正常钻探范围内保持执行器和进给机构之间的压力关系恒定。
• AMINOALKYL-AMIDOMETHYL-SUBSTITUTED 2- (4-SULPHONYLAMINO) -3-HYDROXY-3 , 4-DIHYDRO-2H-CROMEN-6-YL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL BLOCKERS
  申请人：Abbott Products GmbH

  公开号：EP1871758B1

  公开（公告）日：2010-08-25
• PHARMACEUTICAL COMPOSITIONS COMPRISING NEP-INHIBITORS, INHIBITORS OF THE ENDOGENOUS ENDOTHELIN PRODUCING SYSTEM AND DIURETICS
  申请人：Solvay Pharmaceuticals GmbH

  公开号：EP1853270A1

  公开（公告）日：2007-11-14
• Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
  申请人：Straub Matthias

  公开号：US20060205625A1

  公开（公告）日：2006-09-14

  A novel combination therapy for cardiovascular diseases or conditions, including administering a synergistic combination of at least one inhibitor of neutral endopeptidase, at least one inhibitor of the endogenous endothelin producing system and at least one diuretic, preferably a thiazide diuretic or an adenosine A1 antagonist.
• Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives
  申请人：Moloney Brian

  公开号：US20060252821A1

  公开（公告）日：2006-11-09

  Novel compounds corresponding to formula I, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and n have the meanings given in the description, and also a process for the preparation of these compounds and intermediate products of this process. Furthermore, pharmaceutical compositions comprising the compounds of Formula I and related methods of treatment.