1-(4-(4-Chloro-alpha,alpha-dimethylbenzyl)-2-methoxyphenyl)-1,2,4-triazole-3-carboxamide | 125652-47-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-(4-Chloro-alpha,alpha-dimethylbenzyl)-2-methoxyphenyl)-1,2,4-triazole-3-carboxamide
• 英文别名: 1-[4-[2-(4-chlorophenyl)propan-2-yl]-2-methoxyphenyl]-1,2,4-triazole-3-carboxamide
• CAS: 125652-47-3
• 化学式: C₁₉H₁₉ClN₄O₂
• 分子量: 370.8
• InChiKey: STTFFDLZKCMBQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  83
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• New uses of competitive NMDA receptor antagonists
  申请人：SANDOZ LTD.

  公开号：EP0488959A2

  公开（公告）日：1992-06-03

  The use of competitive NMDA receptor antagonists in the treatment of withdrawal symptoms in patients undergoing drug withdrawal, for suppression of dependence, habituation or addiction on a dependence-producing drug and for preventing or inhibiting opiate tolerance.

  使用竞争性 NMDA 受体拮抗剂治疗戒毒患者的戒断症状，抑制对产生依赖性的药物的依赖、习惯或成瘾，以及预防或抑制鸦片剂耐受性。
• Combination of a NMDA-receptor ligand and a compound with 5-HT6 receptor affinity
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1902733A1

  公开（公告）日：2008-03-26

  The present invention relates to an active substance combination comprising at least one compound with 5-HT6 receptor affinity, and at least NMDA-receptor ligand, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种由至少一种具有 5-HT6 受体亲和力的化合物和至少一种 NMDA 受体配体组成的活性物质组合、一种包含所述活性物质组合的药物，以及使用所述活性物质组合制造药物。
• Topical compositions and methods for treating pain
  申请人：——

  公开号：US20030082214A1

  公开（公告）日：2003-05-01

  Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a surfactant. The compositions induce a local-anesthetic effect when topically administered to intact skin thereby treating or preventing pain, for example, neuropathic pain.

  治疗疼痛的局部组合物和方法。本发明提供水包油乳剂，包含抗抑郁剂、NMDA 受体拮抗剂、亲脂性成分、水和表面活性剂。当局部给药到完整的皮肤上时，这些组合物会产生局部麻醉效果，从而治疗或预防疼痛，例如神经性疼痛。
• Sterile, breathable patch for treating wound pain
  申请人：——

  公开号：US20030082225A1

  公开（公告）日：2003-05-01

  An intradermal patch having a permeable backing coated with a polyvinylpyrrolidone-based hydrogel and containing one or more local anesthetics. The patch is breathable, non-irritating upon application and removal, soothing, and sterile. The patch is useful for treating the pain associated with non-intact skin indications.

  一种皮内贴片，其透气衬底涂有聚乙烯吡咯烷酮水凝胶，并含有一种或多种局部麻醉剂。该贴片透气性好，贴上和取下时无刺激、舒缓且无菌。该贴片可用于治疗与非接触性皮肤指征相关的疼痛。
• NMDA receptor antagonist formulation with reduced neurotoxicity
  申请人：Innovative Drug Delivery Systems, Inc.

  公开号：US20040059003A1

  公开（公告）日：2004-03-25

  The present invention is directed to pharmaceutical compositions of effective amounts of NMDA receptor antagonists and preservative for the administration to a patient in need of effective analgesia and anesthesia. The compositions of the invention advantageously do not cause any significant neurotoxicity. The preferred NMDA receptor antagonist is ketamine. The preferred preservative is benzalkonium chloride.

  本发明涉及有效量的 NMDA 受体拮抗剂和防腐剂的药物组合物，用于给需要有效镇痛和麻醉的患者用药。 本发明的组合物不会引起任何明显的神经毒性。 首选的 NMDA 受体拮抗剂是氯胺酮。 首选的防腐剂是苯扎氯铵。