1-Bromo-4-chloro-2-methyl-3-nitrobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Bromo-4-chloro-2-methyl-3-nitrobenzene
• 英文别名: 1-bromo-4-chloro-2-methyl-3-nitrobenzene
• 化学式: C7H5BrClNO2
• 分子量: 250.48
• InChiKey: QCOCMMMEDDOYPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US20160376278A1

  公开（公告）日：2016-12-29

  The present invention provides a compound of formula (1), wherein R 1 , R 2 , R 3 , R 4a , R 4b , R 5a and R 5b are as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound.