4-Isopropyl-pyrrolidine-3-carboxylic acid methyl ester | 887344-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-Isopropyl-pyrrolidine-3-carboxylic acid methyl ester
• 英文别名: methyl 4-propan-2-ylpyrrolidine-3-carboxylate
• CAS: 887344-14-1
• 化学式: C₉H₁₇NO₂
• 分子量: 171.24
• InChiKey: HDCVOOMNEULPRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SUBSTITUTED PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS<br/>[FR] PYRIMIDINES SUBSTITUÉES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR D2 DE PROSTAGLANDINES
  申请人：AVENTIS PHARMA INC

  公开号：WO2011115940A1

  公开（公告）日：2011-09-22

  The present invention is directed to a substituted pyrimidine compound of formula (I) as set forth herein, or an enantiomer thereof, or a prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound. Formula (I), wherein m and n, independently of each other, are selected from the integers 0, 1, 2 or 3; X and Y, independently of each other, are selected from CR1R2, NR1 or O, wherein X and Y cannot both be O; or X and Y, taken together with the bond between them, form a phenyl group optionally substituted by one to four R3 groups; each Z, independently of each other, is CR1R2; R1, R2 and R3, independently of each other, are selected from the group consisting of H, halogen, aryl, amino, optionally substituted alkyl, optionally substituted alkoxy, and carboxy; wherein optionally substituted alkyl, may be substituted by one to three of the same or different of halogen, carboxy, cyano, hydroxy, amino or aryl.

  本发明涉及一种如下所示的取代嘧啶化合物的公式（I），或其对映体，或其前药或其药学上可接受的盐，或包括这种化合物的药物组合物。该发明还包括一种通过给予患者所述化合物的药学有效量来治疗患者的方法。公式（I）中，其中m和n，彼此独立地从0、1、2或3中选取；X和Y，彼此独立地从CR1R2、NR1或O中选取，其中X和Y不能同时为O；或X和Y，连同它们之间的键，形成一个苯基，该苯基可选择地被1到4个R3基替代；每个Z，彼此独立地为CR1R2；R1、R2和R3，彼此独立地从H、卤素、芳基、氨基、可选择地被取代的烷基、可选择地被取代的烷氧基和羧基的群中选取；其中可选择地被取代的烷基，可以被1到3个相同或不同的卤素、羧基、氰基、羟基、氨基或芳基取代。
• SUBSTITUTED PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP2547672A1

  公开（公告）日：2013-01-23
• PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
  申请人：Hoffmann-La Roche Inc.

  公开号：US20210323977A1

  公开（公告）日：2021-10-21

  The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 and R 4 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.