2-Acetamido-N.N-dimethylbenzamid | 30367-86-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Acetamido-N.N-dimethylbenzamid
• 英文别名: o-Acetamino-dimethylbenzamid；Benzamide, 2-(acetylamino)-N,N-dimethyl-；2-acetamido-N,N-dimethylbenzamide
• CAS: 30367-86-3
• 化学式: C₁₁H₁₄N₂O₂
• mdl: MFCD01195034
• 分子量: 206.244
• InChiKey: JPWHIKJDLCPEEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻乙酰胺苯甲酸內酯 、 二甲胺 生成 2-Acetamido-N.N-dimethylbenzamid
  参考文献：
  名称：

  Acylanthranils. 4. The effect of steric hindrance on selectivity in the reaction of amines with acetylanthranil

  摘要：

  DOI：

  10.1021/jo00424a016

文献信息

• Aromatische phosphine mit substituenten zweiter ordnung—VII
  作者：G.P. Schiemenz、G. Stein

  DOI：10.1016/s0040-4020(01)92776-0

  日期：1970.1
• 4-BROMO-5- (2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (1-(AMINOCARBONYL) ETH-1-YL) AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
  申请人：ELAN PHARMACEUTICALS, INC.

  公开号：EP1633349A1

  公开（公告）日：2006-03-15
• [EN] 4-BROMO-5- (2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (1-(AMINOCARBONYL) ETH-1-YL) AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] DERIVES AMIDE 4-BROMO-5- (2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-ACIDE CARBOXYLIQUE (1-(AMINOCARBONYL)ETH-1-YL) ET COMPOSES CORRESPONDANTS TELS QUE LES ANTAGONISTES DU RECEPTEUR DE LA BRADYKININE DE TYPE B1 POUR LE TRAITEMENT DES MALADIES INFLAMMATOIRES
  申请人：ELAN PHARM INC

  公开号：WO2004098590A1

  公开（公告）日：2004-11-18

  Disclosed are compounds of formulae (I) and (II) that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action. Wherein Z is selected from O, S and NH; Q of formula (III) and the other substituents are as defined in claim 1.
• Acylanthranils. 4. The effect of steric hindrance on selectivity in the reaction of amines with acetylanthranil
  作者：L. A. Errede、J. J. McBrady、H. T. Oien

  DOI：10.1021/jo00424a016

  日期：1977.3