1-[4,4-bis(4-fluorophenyl)-butyl]-4-[3-(3,4-dichlorophenylthio)-2-hydroxypropyl]piperazine | 143759-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4,4-bis(4-fluorophenyl)-butyl]-4-[3-(3,4-dichlorophenylthio)-2-hydroxypropyl]piperazine
• 英文别名: 1-Piperazineethanol, 4-(4,4-bis(4-fluorophenyl)butyl)-alpha-(((3,4-dichlorophenyl)thio)methyl)-；1-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-3-(3,4-dichlorophenyl)sulfanylpropan-2-ol
• CAS: 143759-88-0
• 化学式: C₂₉H₃₂Cl₂F₂N₂OS
• 分子量: 565.555
• InChiKey: TZUGFCWPGYPYIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME
  申请人：POLA CHEMICAL INDUSTRIES INC

  公开号：EP0549796A1

  公开（公告）日：1993-07-07

  A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: wherein R¹ and R² may be the same or different from each other and each represents hydrogen, halogen, alkyl, alkoxy, nitro, amino, hydroxy, optionally esterified carboxyl or trifluoromethyl; R³ represents hydrogen, alkyl, aralkyl, acyl, nitro or optionally esterified carboxymethyl; Ar represents phenyl or naphthyl which may have one to three substituents such as halogen, alkyl, alkoxy, aryloxy, aralkyloxy, nitro, amino, cyano, acyl, hydroxy, optionally esterified carboxyl, substituted sulfonyl, aryl or trifluoromethyl; Z represents sulfur or -NR⁴- wherein R⁴ represents hydrogen, alkyl, aralkyl, acyl, aryl, substituted sulfonyl or optionally esterified carboxyl; m represents a number of 1 to 5; and n represents a number of 0 to 5.

  由通式（1）代表的二苯基哌嗪衍生物、其盐，以及以其为有效成分的循环器官用药： 其中 R¹ 和 R² 可以相同或互不相同，各自代表氢、卤素、烷基、烷氧基、硝基、氨基、羟基、任选酯化羧基或三氟甲基；R³ 代表氢、烷基、芳烷基、酰基、硝基或任选酯化羧甲基；Ar 代表苯基或萘基，可具有一至三个取代基，如卤素、烷基、烷氧基、芳氧基、芳烷氧基、硝基、氨基、氰基、酰基、羟基、任选酯化羧基、取代磺酰基、芳基或三氟甲基；Z 代表硫或-NR⁴-，其中 R⁴ 代表氢、烷基、芳烷基、酰基、芳基、取代的磺酰基或任选酯化的羧基；m 代表 1 至 5 的数字；以及 n 代表 0 至 5 的数字。
• Diphenylpiperazine derivative and drug for circulatory organ containing the same
  申请人：POLA CHEMICAL INDUSTRIES, INC.

  公开号：EP0612738A1

  公开（公告）日：1994-08-31

  A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: wherein R¹ and R² may be the same or different from each other and each represents hydrogen, halogen, alkyl, alkoxy, nitro, amino, hydroxy, optionally esterified carboxyl or trifluoromethyl; R³ represents hydrogen, alkyl, aralkyl, acyl, nitro or optionally esterified carboxymethyl; Ar represents phenyl or naphthyl which may have one to three substituents such as halogen, alkyl, alkoxy, aryloxy, aralkyloxy, nitro, amino, cyano, acyl, hydroxy, optionally esterified carboxyl, substituted sulfonyl, aryl or trifluoromethyl; Z represents sulfur or -NR⁴- wherein R⁴ represents hydrogen, alkyl, aralkyl, acyl, aryl, substituted sulfonyl or optionally esterified carboxyl; m represents a number of 1 to 5; and n represents a number of 0 to 5.

  由通式（1）代表的二苯基哌嗪衍生物、其盐，以及以其为有效成分的循环器官用药： 其中 R¹ 和 R² 可以相同或互不相同，各自代表氢、卤素、烷基、烷氧基、硝基、氨基、羟基、任选酯化羧基或三氟甲基；R³ 代表氢、烷基、芳烷基、酰基、硝基或任选酯化羧甲基；Ar 代表苯基或萘基，可具有一至三个取代基，如卤素、烷基、烷氧基、芳氧基、芳烷氧基、硝基、氨基、氰基、酰基、羟基、任选酯化羧基、取代磺酰基、芳基或三氟甲基；Z 代表硫或-NR⁴-，其中 R⁴ 代表氢、烷基、芳烷基、酰基、芳基、取代的磺酰基或任选酯化的羧基；m 代表 1 至 5 的数字；以及 n 代表 0 至 5 的数字。
• US5391552A
  申请人：——

  公开号：US5391552A

  公开（公告）日：1995-02-21