1,4-dimethyl-3-(pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[c]pyridine | 1394159-38-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,4-dimethyl-3-(pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[c]pyridine
• 英文别名: 1,4-dimethyl-3-pyrrolidin-1-yl-6,7-dihydro-5H-cyclopenta[c]pyridine
• CAS: 1394159-38-6
• 化学式: C₁₄H₂₀N₂
• 分子量: 216.326
• InChiKey: AEAFXYFUMOVCGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-氰基吡咯烷 、 壬-2,7-二炔 在 1,1'-(pyridine-2,6-diyl)bis(N-mesitylmethanimine) 、 iron(II) chloride 、 锌 作用下， 以 苯 为溶剂， 反应 7.0h， 以84%的产率得到1,4-dimethyl-3-(pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[c]pyridine
  参考文献：
  名称：

  Iron-Catalyzed Formation of 2-Aminopyridines from Diynes and Cyanamides

  摘要：

  Diynes and cyanamides undergo an iron-catalyzed [2 + 2 + 2] cycloaddition to form highly substituted 2-aminopyridines in an atom-efficient manner that is both high yielding and regioselective. This system was also used to cyclize two terminal alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.

  DOI：

  10.1021/jo3012418

文献信息

• Iron-Catalyzed Formation of 2-Aminopyridines from Diynes and Cyanamides
  作者：Timothy K. Lane、Brendan R. D’Souza、Janis Louie

  DOI：10.1021/jo3012418

  日期：2012.9.7

  Diynes and cyanamides undergo an iron-catalyzed [2 + 2 + 2] cycloaddition to form highly substituted 2-aminopyridines in an atom-efficient manner that is both high yielding and regioselective. This system was also used to cyclize two terminal alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.