N-(1,3-dihydrobenzimidazol-2-ylidene)-2-methoxy-4-methylsulfanylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1,3-dihydrobenzimidazol-2-ylidene)-2-methoxy-4-methylsulfanylbenzamide
• 化学式: C₁₆H₁₅N₃O₂S
• 分子量: 313.4
• InChiKey: AJNXREZTYLMNJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Amyloid precursor protein MRNA blockers for treating Down syndrome and Alzheimer's disease
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US10022357B2

  公开（公告）日：2018-07-17

  The present disclosure relates to methods for treating a neurodegenerative disorder by administering an effective amount of an agent that inhibits or reduces translation of amyloid precursor protein. In some embodiments, the neurodegenerative disorder is Alzheimer's disease or Down syndrome. Also disclosed are methods for decreasing amyloid-beta production in a subject's brain. Further disclosed is a method for restoring or maintaining iron homeostasis in a subject's brain.

  本公开涉及通过施用有效量的抑制或减少淀粉样前体蛋白翻译的制剂来治疗神经退行性疾病的方法。在某些实施方案中，神经退行性疾病是阿尔茨海默病或唐氏综合征。还公开了减少受试者大脑中淀粉样蛋白-β产生的方法。还公开了一种恢复或维持受试者大脑中铁平衡的方法。
• [EN] AMYLOID PRECURSOR PROTEIN MRNA BLOCKERS FOR TREATING DOWN SYNDROME AND ALZHEIMER'S DISEASE<br/>[FR] BLOQUEURS DE L'ARN MESSAGER DE PROTÉINE PRÉCURSEUR DE L'AMYLOÏDE PERMETTANT DE TRAITER LE SYNDROME DE DOWN ET LA MALADIE D'ALZHEIMER
  申请人：GEN HOSPITAL CORP

  公开号：WO2014179303A1

  公开（公告）日：2014-11-06

  The present disclosure relates to methods for treating a neurodegenerative disorder by administering an effective amount of an agent that inhibits or reduces translation of amyloid precursor protein. In some embodiments, the neurodegenerative disorder is Alzheimer's disease or Down syndrome. Also disclosed are methods for decreasing amyloid-beta production in a subject's brain. Further disclosed is a method for restoring or maintaining iron homeostasis in a subject's brain.