3,17-bis(ethylenedioxy)-11α-hydroxy-5α-androstane | 117572-16-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3,17-bis(ethylenedioxy)-11α-hydroxy-5α-androstane
• CAS: 117572-16-4
• 化学式: C₂₃H₃₆O₅
• 分子量: 392.536
• InChiKey: HPSRFIFFILYAGW-WYLBFHJUSA-N

物化性质

• 沸点：
  514.3±50.0 °C(predicted)
• 密度：
  1.22±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.49
• 重原子数：
  28.0
• 可旋转键数：
  0.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.15
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  3,17-bis(ethylenedioxy)-11α-hydroxy-5α-androstane 在 盐酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以86%的产率得到11α-hydroxy-5α-androstan-3,17-dione
  参考文献：
  名称：

  A direct radioimmunoassay for 5α-androstane-3α,17β-diol 17-glucuronide

  摘要：

  Synthesis of the 11-alpha-hemiglutaryl-derivative of 5-alpha-androstane-3-alpha, 17-beta-diol 17-glucuronide (androstanediol-17G) starting from androsta-4,9(11)-diene-3,17-dione through a 10-step sequence and the preparation of its bovine serum albumin conjugate is described. By using this conjugate, antiserum was raised in rabbits which proved to be very specific for androstanediol-17G. A direct radioimmunoassay using a double antibody procedure is described for the measurement of androstanediol-17G from plasma without prior chromatography.

  DOI：

  10.1016/0039-128x(92)90105-i
• 作为产物：
  描述：

  雄甾-4,9(11)-二烯-3,17-二酮 在 chromium(VI) oxide 、 sodium hydroxide 、 硼烷四氢呋喃络合物 、 lithium 、 对甲苯磺酸 、 乙胺 、 原甲酸三乙酯 、 叔丁醇 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 3,17-bis(ethylenedioxy)-11α-hydroxy-5α-androstane
  参考文献：
  名称：

  A direct radioimmunoassay for 5α-androstane-3α,17β-diol 17-glucuronide

  摘要：

  Synthesis of the 11-alpha-hemiglutaryl-derivative of 5-alpha-androstane-3-alpha, 17-beta-diol 17-glucuronide (androstanediol-17G) starting from androsta-4,9(11)-diene-3,17-dione through a 10-step sequence and the preparation of its bovine serum albumin conjugate is described. By using this conjugate, antiserum was raised in rabbits which proved to be very specific for androstanediol-17G. A direct radioimmunoassay using a double antibody procedure is described for the measurement of androstanediol-17G from plasma without prior chromatography.

  DOI：

  10.1016/0039-128x(92)90105-i

文献信息

• Turner, Alan B.; Leersum, Philip T. van, Journal of the Chemical Society. Perkin transactions I, 1988, p. 1653 - 1658
  作者：Turner, Alan B.、Leersum, Philip T. van

  DOI：——

  日期：——
• A direct radioimmunoassay for 5α-androstane-3α,17β-diol 17-glucuronide
  作者：Pemmaraju N. Rao、Angela M. Rodriguez、Perry H. Moore、James W. Cessac

  DOI：10.1016/0039-128x(92)90105-i

  日期：1992.5

  Synthesis of the 11-alpha-hemiglutaryl-derivative of 5-alpha-androstane-3-alpha, 17-beta-diol 17-glucuronide (androstanediol-17G) starting from androsta-4,9(11)-diene-3,17-dione through a 10-step sequence and the preparation of its bovine serum albumin conjugate is described. By using this conjugate, antiserum was raised in rabbits which proved to be very specific for androstanediol-17G. A direct radioimmunoassay using a double antibody procedure is described for the measurement of androstanediol-17G from plasma without prior chromatography.