N-(4-oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)-2-(trifluoromethyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)-2-(trifluoromethyl)benzamide
• 英文别名: N-(4-oxo-5,6,7,8-tetrahydro-[1,3]thiazolo[5,4-c]azepin-2-yl)-2-(trifluoromethyl)benzamide
• 化学式: C₁₅H₁₂F₃N₃O₂S
• 分子量: 355.3
• InChiKey: HNQCHHPVEISTJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  99.3
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING HEDGEHOG PATHWAY
  申请人：Shrivastava Shivani

  公开号：US20220233539A1

  公开（公告）日：2022-07-28

  The present invention relates to the use of compositions and methods for treating or preventing a cancer condition in a subject. The use of composition comprises methods of treating or preventing cancer with agents that inhibit Hedgehog pathway activity. The pharmaceutical composition will further comprise agents that inhibit Smoothened receptor and/or Gli transcription in a subject.