(2-hydroxyethyl)methyldicetylammonium chloride | 57322-84-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2-hydroxyethyl)methyldicetylammonium chloride
• 英文别名: N,N-di-n-hexadecyl-N-methyl-N-(2-hydroxyethyl)ammonium chloride；N,N-di-n-hexadecyl-N-2-hydroxyethyl-N-methylammonium chloride；Dihexadecyl-(2-hydroxyethyl)-methylazanium;chloride
• CAS: 57322-84-6
• 化学式: C₃₅H₇₄NO*Cl
• 分子量: 560.432
• InChiKey: XICSHSCSQMDVQC-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  8.39
• 重原子数：
  38
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  异氰酸丙基三乙氧基硅烷 、 (2-hydroxyethyl)methyldicetylammonium chloride 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 N-[3-(triethoxysilyl)propyl] O-2-(dicetylmethylammonium)ethyl urethane
  参考文献：
  名称：

  Synthesis and catalytic activity of periodic mesoporous materials incorporating gold nanoparticles

  摘要：

  通过一锅法合成得到了含金纳米颗粒的介孔二氧化硅（mpAu–SiO2），起始材料为四乙氧基硅烷（TEOS）和以N-[3-(三乙氧基硅基)丙基]O-2(二硬脂基甲基铵)乙基脲为稳定剂的胶体金颗粒（2–5纳米）。这种稳定剂配体通过季铵离子与金纳米颗粒相互作用，其长链也显示出与十六烷基三甲基铵表面活性剂的亲和性。另一方面，三乙氧基硅基团适合与TEOS在二氧化硅形成过程中发生共凝聚。mpAu–SiO2材料的周期性介孔结构通过X射线衍射、透射电子显微镜和煅烧mpAu–SiO2的等温气体吸附进行评估（SBET 488 m2×g−1，孔径3.5纳米）。该材料在无溶剂的好氧条件下对二级醇氧化成酮的反应中表现出高活性和可重复使用性。

  DOI：

  10.1039/b507418e
• 作为产物：
  描述：

  O-tert-butyldimethylsilyl N-2-hydroxyethyl-N,N-di-n-hexadecylamine 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 为溶剂， 反应 11.0h， 生成 (2-hydroxyethyl)methyldicetylammonium chloride
  参考文献：
  名称：

  Distance of Hydroxyl Functionality from the Quaternized Center Influence DNA Binding and in Vitro Gene Delivery Efficacies of Cationic Lipids with Hydroxyalkyl Headgroups

  摘要：

  In vitro gene delivery efficacies of cationic amphiphiles 1-7 (Scheme 1) were measured by both the reporter gene expression assays in CHO, COS-1, HepG2, and MCF7 cells and by the whole cell histochemical X-gal staining of representative Chinese hamster ovary cells. Our results demonstrated that in vitro gene delivery efficiencies of cationic lipids with hydroxyalkyl headgroups are adversely affected by increased covalent distances between the hydroxyl functionality and the cationic centers. Findings in the DNase I protection experiments and transmission electron microscopic study support the notion that such compromised gene delivery efficacies may originate from poor lipid-DNA binding interactions and significantly increased lipoplex nanosizes.

  DOI：

  10.1021/jm049656j

文献信息

• The reactivity of substrate functionalized surfactant vesicles
  作者：Robert A. Moss、Ronald P. Schrek

  DOI：10.1016/s0040-4039(01)84584-6

  日期：——

  The hydrolysis and thiolysis of active ester-functionalized cationic surfactant vesicles proceed without kinetic resolution of distinct exovesicular and endovesicular reactions.

  活性酯官能化的阳离子表面活性剂囊泡的水解和硫解过程没有明显的囊泡和囊泡反应的动力学拆分。
• Silver dihydrogen citrate compositions
  申请人：Arata B. Andrew

  公开号：US20060051430A1

  公开（公告）日：2006-03-09

  Personal care and home care compositions are disclosed, which include silver dihydrogen citrate. The inventive compositions advantageously take the form of suspensions, pastes, liquids and gels. The inventive compositions also optionally comprise additional ingredients, and are therefore suitable for a wide variety of personal, home and industrial care purposes.

  护理和家居用品组合物被披露，其中包括柠檬酸二氢银。这种创新的组合物有利地采用悬浮液、糊状物、液体和凝胶的形式。这些创新的组合物还可以选择性地包含额外的成分，因此适用于各种个人、家庭和工业护理用途。
• Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
  申请人：Panzner Steffen

  公开号：US20080089932A1

  公开（公告）日：2008-04-17

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种由混合脂质组成的两性脂质体，所述混合物包括阳离子型两性分子、阴离子型两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子型和阴离子型两性分子可被电荷化，所述阳离子型和阴离子型两性分子的相应量被选择为在第一个较低的pH下具有过量的正电荷的阳离子型两性分子，在第二个较高的pH下具有过量的负电荷的阴离子型两性分子，且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述的阳离子型和阴离子型两性分子适合在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• Amphoteric Liposomes, A Method Of Formulating An Amphoteric Liposome And A Method Of Loading An Amphoteric Liposome
  申请人：Panzner Steffen

  公开号：US20120135065A1

  公开（公告）日：2012-05-31

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种两性脂质体，由混合脂质组成，所述混合物包括阳离子两性分子、阴离子两性分子和可选的一个或多个中性两性分子，其中至少一种阳离子和阴离子两性分子是可带电的，并且所述阳离子和阴离子两性分子的相应量被选择为在第一个较低的pH值下存在过量的带正电荷的阳离子两性分子，在第二个较高的pH值下存在过量的带负电荷的阴离子两性分子，并且所述混合物具有介于第一个和第二个pH值之间的等电点；其特征在于所述带正电荷的阳离子和带负电荷的阴离子两性分子被适应在所述等电点处彼此形成脂质盐。还公开了预测在给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• AMPHOTERIC LIPOSOME FORMULATIONS
  申请人：Marina Biotech, Inc.

  公开号：US20160151282A1

  公开（公告）日：2016-06-02

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  由混合脂质组成的两性脂质体，所述混合物包括阳离子两性分子、阴离子两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子和阴离子两性分子可被带电，并且所述阳离子和阴离子两性分子的相应量被选择为在第一个较低pH下存在过量的带正电的阳离子两性分子，在第二个较高pH下存在过量的带负电的阴离子两性分子，并且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述带正电的阳离子和带负电的阴离子两性分子被适应在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。