[[Methoxy(methyl)phosphoryl]-pyridin-2-ylmethyl] 2-[3-(trifluoromethyl)phenoxy]acetate | 904702-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [[Methoxy(methyl)phosphoryl]-pyridin-2-ylmethyl] 2-[3-(trifluoromethyl)phenoxy]acetate
• CAS: 904702-64-3
• 化学式: C₁₇H₁₇F₃NO₅P
• 分子量: 403.295
• InChiKey: VGKJOPDHEYOQGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  74.7
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  methyl (hydroxy(pyridin-2-yl)methyl)(methyl)phosphinate 、 2-[3-(三氟甲基)苯氧基]乙酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以62%的产率得到[[Methoxy(methyl)phosphoryl]-pyridin-2-ylmethyl] 2-[3-(trifluoromethyl)phenoxy]acetate
  参考文献：
  名称：

  Synthesis and Biological Activity of α -Oxo-2-Pyridyl Methyl Phosphinates

  摘要：

  In an attempt to discover novel compounds with high activity and low toxicity, a series of new O,O-dimethyl-alpha-(substituted phenoxyacetoxy)-2-pyridyl methyl phosphinates, 5a-5h, have been designed and synthesized by the reaction of substituted phenoxyacetic chloride with 1-hydroxy-2-pyridyl methyl phosphinate, The structures of all new compounds were characterized by elementary analysis, IR, (1)H NMR, and MS spectroscopies. The results of preliminary bioassay indicate that most of the target compounds have excellent inhibitory activities on barnyard grass and rape.

  DOI：

  10.1080/10426500701792974

文献信息

• Synthesis and Biological Activity of α -Oxo-2-Pyridyl Methyl Phosphinates
  作者：Tao Wang、Hong Wu He

  DOI：10.1080/10426500701792974

  日期：2008.7.4

  In an attempt to discover novel compounds with high activity and low toxicity, a series of new O,O-dimethyl-alpha-(substituted phenoxyacetoxy)-2-pyridyl methyl phosphinates, 5a-5h, have been designed and synthesized by the reaction of substituted phenoxyacetic chloride with 1-hydroxy-2-pyridyl methyl phosphinate, The structures of all new compounds were characterized by elementary analysis, IR, (1)H NMR, and MS spectroscopies. The results of preliminary bioassay indicate that most of the target compounds have excellent inhibitory activities on barnyard grass and rape.