US9238626, (+/-)-(Ie) HCl

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: US9238626, (+/-)-(Ie) HCl
• 英文别名: N-[[4-[[(7-chloro-15-methyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-yl)amino]methyl]phenyl]methyl]-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxamide
• 化学式: C₄₀H₃₂ClN₃O₅
• 分子量: 670.1
• InChiKey: BMUWOXBZGNXOSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  49
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Beta-Amyloid-Directed Multitarget Compounds For The Treatment Of Alzheimer's Disease
  申请人：UNIVERSITAT DE BARCELONA

  公开号：US20150099776A1

  公开（公告）日：2015-04-09

  The compounds of formula (I), or its pharmaceutically acceptable salts, or any stereoisomer or mixture thereof, wherein: R 1 is a (C 1 -C 2 ) alkyl radical; R 2 and R 3 are radicals independently selected from the group consisting of F, Cl and methyl R 4 is H or OH; A is a birradical selected from the group consisting of —(CH 2 ) n — and —(CH 2 )-phenyl-(CH 2 )—; t is an integer from 0 to 1; and n is an integer from 8 to 15, are useful for the treatment of Alzheimer's disease.
• US9238626B2
  申请人：——

  公开号：US9238626B2

  公开（公告）日：2016-01-19