tert-butyl 6-oxo-6-(2-oxooxazolidin-3-yl)hexyloxycarbamate | 1101207-23-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: tert-butyl 6-oxo-6-(2-oxooxazolidin-3-yl)hexyloxycarbamate
• 英文别名: tert-butyl N-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexoxy]carbamate
• CAS: 1101207-23-1
• 化学式: C₁₄H₂₄N₂O₆
• 分子量: 316.354
• InChiKey: GYAJOCDRHCYXBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  94.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl 6-oxo-6-(2-oxooxazolidin-3-yl)hexyloxycarbamate 、 三氟乙酸 以 二氯甲烷 为溶剂， 反应 0.58h， 以99%的产率得到O-(6-oxo-6-(2-oxooxazolidin-3-yl)hexyl)hydroxylammonium trifluoroacetate
  参考文献：
  名称：

  A versatile radical based approach to O-alkylated hydroxylamines and oximes

  摘要：

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.113
• 作为产物：
  描述：

  tert-butyl 3-(ethoxycarbonothioylthio)-6-oxo-6-(2-oxooxazolidin-3-yl)hexyloxycarbamate 在 偶氮二异丁腈 、 次磷酸 、 三乙胺 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以87%的产率得到tert-butyl 6-oxo-6-(2-oxooxazolidin-3-yl)hexyloxycarbamate
  参考文献：
  名称：

  A versatile radical based approach to O-alkylated hydroxylamines and oximes

  摘要：

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.113

文献信息

• A versatile radical based approach to O-alkylated hydroxylamines and oximes
  作者：Béatrice Quiclet-Sire、Daniel Woollaston、Samir Z. Zard

  DOI：10.1016/j.tet.2008.08.113

  日期：2008.12

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.