1-(2-Fluoro-5-methylphenyl)-5-methoxy-4-oxopyridazine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Fluoro-5-methylphenyl)-5-methoxy-4-oxopyridazine-3-carboxylic acid
• 英文别名: 1-(2-fluoro-5-methylphenyl)-5-methoxy-4-oxopyridazine-3-carboxylic acid
• 化学式: C₁₃H₁₁FN₂O₄
• 分子量: 278.24
• InChiKey: SHLHFDACPJYFAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  79.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PYRIDAZINONE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS AND METHODS OF TREATING DISORDERS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20170114044A1

  公开（公告）日：2017-04-27

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I 0 ) wherein R 1 represents a substituent, R 2 represents a hydrogen atom, or a substituent, R 3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.
• US9550756B2
  申请人：——

  公开号：US9550756B2

  公开（公告）日：2017-01-24