4-Chloro-3-[[5-(6-fluoropyridin-3-yl)thiophen-2-yl]methyl]aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chloro-3-[[5-(6-fluoropyridin-3-yl)thiophen-2-yl]methyl]aniline
• 英文别名: 4-chloro-3-[[5-(6-fluoropyridin-3-yl)thiophen-2-yl]methyl]aniline
• 化学式: C₁₆H₁₂ClFN₂S
• 分子量: 318.8
• InChiKey: VDJVKUOXQGQPAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Process for the preparation of compounds useful as inhibitors of SGLT2
  申请人：Houpis Ioannis Nicolaos

  公开号：US10544135B2

  公开（公告）日：2020-01-28

  The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

  本发明涉及一种制备对存在于肠道或肾脏中的钠依赖性葡萄糖转运体（SGLT）具有抑制活性的化合物的新工艺。
• PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT2
  申请人：Janssen Pharamceutica NV

  公开号：US20190194177A1

  公开（公告）日：2019-06-27

  The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.