3-methyl-5-[(Z)-6-[(E)-(1-oxo-1-phosphanylpropan-2-ylidene)amino]oxyhexoxyiminomethyl]benzaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-5-[(Z)-6-[(E)-(1-oxo-1-phosphanylpropan-2-ylidene)amino]oxyhexoxyiminomethyl]benzaldehyde
• 化学式: C₁₈H₂₅N₂O₄P
• 分子量: 364.4
• InChiKey: ZJESDJAVKURTJK-WUOTZJKISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• SITE-SPECIFIC CHEMICAL MODIFICATION OF PROTEINS AT THEIR N-TERMINI, ENABLING THE FORMATION OF HOMOGENEOUS ADDUCTS
  申请人：KRANTZ Alexander

  公开号：US20100099649A1

  公开（公告）日：2010-04-22

  Site-specific modifications of proteins at their N-termini are provided. In particular, a chemical modification of proteins at their N-termini via a transamination reaction to form homogeneous adducts such as, the corresponding oxime derivatives is provided. Methods of making and using the adducts in radio-labelling, molecular imaging applications, and treatment of disorders such as cancer, Crohn's disease, arthritis, atherothrombosis and plaque rupture are also provided.
• US8431521B2
  申请人：——

  公开号：US8431521B2

  公开（公告）日：2013-04-30