1-methyl-2-oxopiperidine-3-carboxylic acid | 37464-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-methyl-2-oxopiperidine-3-carboxylic acid
• 英文别名: 1-Methyl-2-oxo-3-piperidinecarboxylic Acid
• CAS: 37464-03-2
• 化学式: C₇H₁₁NO₃
• 分子量: 157.169
• InChiKey: AAMWBMZCAOJKJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-methyl-2-oxopiperidine-3-carboxylic acid 在 2-氯-1-甲基吡啶碘化物 、 copper(II) acetate monohydrate 、 三乙胺 作用下， 以 二氯甲烷 、 均三甲苯 为溶剂， 反应 17.5h， 生成 1,1'-dimethylspiro[indoline-3,3'-piperidine]-2,2'-dione
  参考文献：
  名称：

  Copper-catalysed approach to spirocyclic oxindoles via a direct C–H, Ar-H functionalisation

  摘要：

  A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.01.120
• 作为产物：
  描述：

  1-甲基-2-哌啶酮 在 5%-palladium/activated carbon 、 氢气 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 2.17h， 生成 1-methyl-2-oxopiperidine-3-carboxylic acid
  参考文献：
  名称：

  Copper-catalysed approach to spirocyclic oxindoles via a direct C–H, Ar-H functionalisation

  摘要：

  A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.01.120

文献信息

• PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
  申请人：Philippe Michel

  公开号：US20100028280A1

  公开（公告）日：2010-02-04

  The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

  该发明涉及一种直发角蛋白纤维的拉直过程，包括：(i)将至少两种变性剂含有的拉直组合物涂抹到角蛋白纤维上的步骤，(ii)使用加热装置将角蛋白纤维的温度升高至110至250°C的步骤。
• [EN] N-ACETYLSEROTONIN DERIVATIVES AS TRKB ACTIVATORS AND USES THEREOF<br/>[FR] DÉRIVÉS DE N-ACÉTYLSÉROTONINE EN TANT QU'ACTIVATEURS DE TRKB ET LEURS UTILISATIONS
  申请人：UNIV EMORY

  公开号：WO2021222577A1

  公开（公告）日：2021-11-04

  This disclosure relates to N-acetylserotonin derivatives that have neuroprotective properties for uses in treating or preventing traumatic brain injury, vision loss, neuronal cell ischemia, and retinal degenerative diseases. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising the N-acetylserotonin derivative and a pharmaceutically acceptable excipient.

  本公开涉及具有神经保护特性的N-乙酰褪黑激素衍生物，用于治疗或预防创伤性脑损伤、视力丧失、神经细胞缺血和视网膜退行性疾病。在某些实施例中，本公开涉及包含N-乙酰褪黑激素衍生物和药用可接受的赋形剂的药物组合物。
• PROCESS FOR PRODUCTION OF CINNAMIDE DERIVATIVE
  申请人：Shimomura Naoyuki

  公开号：US20090270623A1

  公开（公告）日：2009-10-29

  A compound (8) represented by the formula: (8) wherein R 1 represents a 6- to 14-membered aromatic hydrocarbon ring group which may have a substituent; and n represents 0 to 2, can be produced with good efficiency by reacting a compound (3) represented by the formula: (3) wherein R 1 and n are as defined above; and Q represents a single bond or —CH(Y)— where Y represents a hydrogen atom or a C1-6 alkyl group] with 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the presence of a base.

  式（8）表示的化合物为：（8）其中R1代表一个6-至14-成员的芳香烃环基团，可以具有取代基；n表示0至2，可以通过在碱存在下将式（3）表示的化合物与3-甲氧基-4-(4-甲基-1H-咪唑-1-基)苯甲醛反应而高效地产生，式（3）中R1和n的定义如上；Q代表单键或—CH(Y)—，其中Y代表氢原子或C1-6烷基团。
• Waldheim, G.; Moehrle, H.; Ruediger, S., Journal fur praktische Chemie (Leipzig 1954), 1990, vol. 332, # 1, p. 15 - 27
  作者：Waldheim, G.、Moehrle, H.、Ruediger, S.

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS TO IMPROVE PLANT HEALTH AND/OR PLANT PERFORMANCE
  申请人：PLANTRESPONSE BIOTECH, S.L.

  公开号：US20210051963A1

  公开（公告）日：2021-02-25

  The present invention is directed to methods and compositions for increasing a growth characteristic of a plant, increasing nutrient use efficiency of a plant, or improving a plant's ability to overcome biotic or abiotic stress comprising applying a composition comprising a fungal mycelia extract comprising piperidine and/or an analogue thereof (e.g., 6-oxopiperidine-2-carboxylic acid) and/or a salt thereof (e.g., 6-oxopiperidine-2-carboxylate), or any combination thereof to a plant, plant part, or to a propagation material of the plant.