3-(2-Pyridylmethylamino)-propylamin | 20948-06-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(2-Pyridylmethylamino)-propylamin
• 英文别名: 3-Amino-propyl-(pyridyl-(2)-methyl)-amin；N-(2-pyridylmethyl)trimethylenediamine；N'-(pyridin-2-ylmethyl)propane-1,3-diamine
• CAS: 20948-06-5
• 化学式: C₉H₁₅N₃
• 分子量: 165.238
• InChiKey: YLAKXGRIFZNJJM-UHFFFAOYSA-N

物化性质

• 沸点：
  284.1±20.0 °C(Predicted)
• 密度：
  1.026±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate 、 3-(2-Pyridylmethylamino)-propylamin 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors

  摘要：

  Pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives are new chemical entities with good and attractive druglikeness properties. A series of pyrazolo-pyrido-diazepine dione analogs demonstrated to be particularly amenable to lead optimization through a couple of cycles in order to improve specificity for isoforms Nox4 and Nox1 and had excellent pharmacokinetic parameters by oral route. Several molecules such as compound 7c proved to be highly potent in in vitro assays on human lung fibroblasts differentiation as well as in curative murine models of bleomycin-induced pulmonary fibrosis with superior efficiency over Pirfenidone. Pyrazolo-pyrido-diazepine dione derivatives targeting Nox4 and Nox1 isoforms appear highly promising therapeutics for the treatment of idiopathic pulmonary fibrosis. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.016

文献信息

• Composition, synthesis and therapeutic applications of polyamines
  申请人：——

  公开号：US20030013772A1

  公开（公告）日：2003-01-16

  The invention relates to the preparation of novel polyamines, such as derivatives of 1,3-bis-[(2′-aminoethyl)-amino]propane (2,3,2-tetramine) and 1,4,8,11-tetraazacyclotetradecane (cyclam), which can be used to treat mitochondrial and degenerative diseases. Accordingly, in one aspect the invention is directed to compounds of the formula: 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 may be the same or different and are hydrogen, alkyl, aryl, cycloalkyl, amino acid, glutathione, urate, ascorbate, estrogen, dehydroepiandrosterone, redox stabilizing substituents, a quinone, glutamate, succinate, —(CH 2 ) n [XCH 2 ) n ]NH 2 — wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon, or heterocycle wherein R 1 to R 6 taken together are —(CH 2 XCH 2 ) n — wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon. M, n, and p may be the same or different and are bridging groups of variable length from 3-12 carbons. X 1 and X 2 may be the same or different and are nitrogen, sulfur, phosporous or carbon.

  本发明涉及制备新型聚胺，如1,3-双[（2'-氨基乙基）-氨基]丙烷（2,3,2-四胺）和1,4,8,11-四氮杂环十四烷（环戊二烯），可用于治疗线粒体和退行性疾病。因此，本发明在一个方面涉及以下式子的化合物：1其中R1、R2、R3、R4、R5和R6可以相同或不同，且为氢、烷基、芳香基、环烷基、氨基酸、谷胱甘肽、尿酸、抗坏血酸、雌激素、去氢表雄酮、氧化还原稳定取代基、醌、谷氨酸、琥珀酸、—（CH2）n[XCH2]nNH2—（其中n=3-6且X=氮、硫、磷或碳），或杂环，其中R1至R6一起为—（CH2XCH2）n—（其中n=3-6且X=氮、硫、磷或碳）。M、n和p可以相同或不同，且为可变长度的3-12个碳的桥接基团。X1和X2可以相同或不同，且为氮、硫、磷或碳。
• AMINOALCOHOL LIPIDOIDS AND USES THEREOF
  申请人：Mahon Kerry Peter

  公开号：US20110293703A1

  公开（公告）日：2011-12-01

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文描述了通过将胺与环氧末端化合物反应制备氨基醇脂质体的方法。还提供了从商业起始材料制备氨基醇脂质体的方法。氨基醇脂质体可以从外消旋或立体化学纯的环氧化合物制备。氨基醇脂质体或其盐形式最好是可生物降解和生物相容的，并可用于各种药物输送系统。鉴于这些氨基醇脂质体化合物的氨基基团，它们特别适用于多核苷酸的输送。已经制备了包含创新脂质体和多核苷酸的复合物、胶束、脂质体或粒子。创新脂质体也可以用于制备药物输送的微粒。鉴于它们能够缓冲其周围环境的pH值，它们在输送不稳定剂方面特别有用。
• PROCESS FOR PREPARING GUANIDINO-FUNCTIONAL MONOMERS
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20160096802A1

  公开（公告）日：2016-04-07

  A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.

  制备含有胍基官能团、自由基聚合化合物的过程包括：（a）混合（1）一种胺化合物，该胺化合物包括（i）至少一个一级脂肪族氨基团和（ii）至少一个二级脂肪族氨基团、一级芳香族氨基团或二级芳香族氨基团，以及（2）一种胍基化试剂；（b）使胺化合物和胍基化试剂发生反应形成胍基化胺化合物；（c）混合（1）胍基化胺化合物和（2）一种反应单体，该反应单体包括（i）至少一个乙烯基不饱和基团和（ii）至少一个与氨基反应的基团；（d）使胍基化胺化合物和反应单体发生反应形成含有胍基官能团、自由基聚合化合物。
• Nitromethylen-Derivate, Verfahren zur ihrer Herstellung sowie insektizide, mitizide und nematizide Mittel
  申请人：NIHON TOKUSHU NOYAKU SEIZO K.K.

  公开号：EP0154178A1

  公开（公告）日：1985-09-11

  Es werden neue Nitromethylen-Derivate der allgemeinen Formel bereitgestellt, in der R ein Wasserstoff-Atom oder eine niedere Alkyl-Gruppe bezeichnet, m für 2, 3 oder 4 steht und n für 0, 1, 2 oder 3 steht. Die neuen Verbindungen werden durch Umsetzung von Verbindungen der Formel mit solchen der Formel erhalten und zeigen sehr gute insektizide, mitizide und nematizide Eigenschaften.

  通式如下的新硝基亚甲基衍生物 其中 R 表示氢原子或低级烷基，m 为 2、3 或 4，n 为 0、1、2 或 3。 这些新化合物是通过将通式为 与式 并表现出非常好的杀虫、杀螨虫和杀线虫特性。
• Process for preparing guanidino-functional monomers
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10239828B2

  公开（公告）日：2019-03-26

  A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.

  一种制备可自由基聚合的胍基官能团化合物的工艺包括(a)将(1)包含(i)至少一个伯脂族氨基和(ii)至少一个仲脂族氨基、伯芳族氨基或仲芳族氨基的胺化合物与(2)一种鸟苷酸化剂结合；(b)允许或诱导胺化合物与鸟苷酸化剂反应以形成鸟苷酸化胺化合物；(c) 将(1)鸟苷化胺化合物和(2)反应性单体结合，反应性单体包括(i)至少一个乙 烯不饱和基团和(ii)至少一个与氨基反应的基团；以及 (d) 允许或诱导鸟苷化胺化合物和反应性单体反应，以形成鸟苷酸官能团、可 自由基聚合的化合物。