8-Bromo-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,2-g]quinoline | 179894-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 8-Bromo-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,2-g]quinoline
• 英文别名: 8-bromo-2,2,4-trimethyl-1,10-dihydroindeno[1,2-g]quinoline
• CAS: 179894-52-1
• 化学式: C₁₉H₁₈BrN
• 分子量: 340.263
• InChiKey: GVOMUZMTQPGWTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  8-Bromo-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,2-g]quinoline 、 碘甲烷 在 双(三甲基硅烷基)氨基钾 作用下， 生成 8-Bromo-2,2,4,10-tetramethyl-2,10-dihydro-1H-indeno[1,2-g]quinoline
  参考文献：
  名称：

  Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines

  摘要：

  A series of nonsteroidal human progesterone receptor (hPR) antagonists based on conformationally-restricted analogues of a 6-aryl-1,2-dihydro-2,2,4-trimethylquinoline pharmacophore were synthesized and evaluated for their ability to bind to the human progesterone receptor and inhibit progesterone-stimulated reporter gene expression in mammalian cells, (C) 1998 Elsevier Science Ltd. AU rights reserved.

  DOI：

  10.1016/s0960-894x(98)00482-x
• 作为产物：
  描述：

  2-氨基-7-溴芴 、 丙酮 在 碘 作用下， 反应 40.0h， 生成 9-Bromo-1,3,3-trimethyl-4,11-dihydro-3H-indeno[2,1-f]quinoline 、 8-Bromo-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,2-g]quinoline
  参考文献：
  名称：

  Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines

  摘要：

  A series of nonsteroidal human progesterone receptor (hPR) antagonists based on conformationally-restricted analogues of a 6-aryl-1,2-dihydro-2,2,4-trimethylquinoline pharmacophore were synthesized and evaluated for their ability to bind to the human progesterone receptor and inhibit progesterone-stimulated reporter gene expression in mammalian cells, (C) 1998 Elsevier Science Ltd. AU rights reserved.

  DOI：

  10.1016/s0960-894x(98)00482-x

文献信息

• Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines
  作者：Lawrence G. Hamann、David T. Winn、Charlotte L.F. Pooley、Christopher M. Tegley、Sarah J. West、Luc.J. Farmer、Lin Zhi、James P. Edwards、Keith B. Marschke、Dale E. Mais、Mark E. Goldman、Todd K. Jones

  DOI：10.1016/s0960-894x(98)00482-x

  日期：1998.10

  A series of nonsteroidal human progesterone receptor (hPR) antagonists based on conformationally-restricted analogues of a 6-aryl-1,2-dihydro-2,2,4-trimethylquinoline pharmacophore were synthesized and evaluated for their ability to bind to the human progesterone receptor and inhibit progesterone-stimulated reporter gene expression in mammalian cells, (C) 1998 Elsevier Science Ltd. AU rights reserved.