N-[4-(trifluoromethoxy)phenyl]isonicotinamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(trifluoromethoxy)phenyl]isonicotinamide
• 英文别名: N-[4-(trifluoromethoxy)phenyl]pyridine-4-carboxamide
• 化学式: C₁₃H₉F₃N₂O₂
• 分子量: 282.22
• InChiKey: XNOXATIDKXASQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS
  申请人：Euro-Celtique S.A.

  公开号：EP1432419A1

  公开（公告）日：2004-06-30
• [EN] ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS<br/>[FR] PYRIDINECARBOXAMIDES SUBSTITUES PAR ARYLE ET LEUR UTILISATION COMME AGENTS BLOQUANTS DU CANAL SODIQUE
  申请人：EURO CELTIQUE SA

  公开号：WO2003022276A1

  公开（公告）日：2003-03-20

  This invention relates aryl substituted pyridines of Formula (I),or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.