2-[(5Z)-5-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[(5Z)-5-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide
• 化学式: C₂₄H₁₈N₄O₄S₂
• 分子量: 490.6
• InChiKey: JUTNDAXBFNYSLA-UNOMPAQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  159
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• MYC MODULATORS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160168165A1

  公开（公告）日：2016-06-16

  The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc inhibitors) and may be useful in treating in a subject in need thereof diseases associated with Myc and proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.

  本公开提供式(I-a)、式(I)和式(II)的化合物。本文所描述的化合物可能是Myc调节剂（例如Myc抑制剂），并且可能有用于治疗与Myc和增殖性疾病（例如癌症）相关的患者。本公开还提供了包括所述化合物的药物组合物、试剂盒、方法和用途。
• Myc modulators and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10017520B2

  公开（公告）日：2018-07-10

  The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc inhibitors) and may be useful in treating in a subject in need thereof diseases associated with Myc and proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.

  本公开提供了式(I-a)、式(I)和式(II)化合物。本文所述的化合物可以是Myc调节剂（如Myc抑制剂），可用于治疗有需要的受试者与Myc相关的疾病和增殖性疾病（如癌症）。本公开还提供了包括本文所述化合物的药物组合物、试剂盒、方法和用途。