Dimethyl (tetrahydro-3,3-diphenyl-2-furylidene) ammonium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Dimethyl (tetrahydro-3,3-diphenyl-2-furylidene) ammonium
• 英文别名: (3,3-diphenyloxolan-2-ylidene)-dimethylazanium
• 化学式: C18H20NO+
• 分子量: 266.4
• InChiKey: LFTJLBZHKDXXBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  12.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  、 Dimethyl (tetrahydro-3,3-diphenyl-2-furylidene) ammonium 、 4-(4-溴苯基)哌啶-4-醇盐酸盐 、 disodium;carbonate 、 碘化钾 在 sodium hydroxide 、 4-甲基-2-戊酮 作用下， 以 水 、 4-甲基-2-戊酮 为溶剂， 反应 14.0h， 以yielding 4-(p-bromophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenylpiperidine-1-butyramide hydrate的产率得到4-(p-bromophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenylpiperidine-1-butyramide hydrate
  参考文献：
  名称：

  Spray formulations of antihyperalgesic opiates and method of treating

  摘要：

  抗高痛觉的阿片类喷雾制剂，在溶剂混合物中具有251至1,280的外周选择性，该溶剂混合物中含有最多15％w / w的乙醇，所选乙醇来自乙基，丙基和异丙醇组成的群体，同时含有大于或等于85％w / w的水。

  公开号：

  US05811078A1

文献信息

• Benzomorphan Analogs and the Use Thereof
  申请人：LOCKMAN Jeffrey

  公开号：US20140135351A1

  公开（公告）日：2014-05-15

  The present invention is directed to Benzomorphan Analog compounds of the Formula I″, Formula IA″, Formula IB″, Formula IC″, or Formula ID″ as shown below; and related Formula I′, Formula IA′, Formula IB′, Formula IC′, or Formula ID′; Formula I, Formula IA, Formula IB, Formula IC, or Formula ID; wherein R 1 , R 2a , R 2b , R 3 and R 4 are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

  本发明涉及以下所示的Formula I″、Formula IA″、Formula IB″、Formula IC″或Formula ID″的苯吗啡类似物化合物；以及相关的Formula I′、Formula IA′、Formula IB′、Formula IC′或Formula ID′；Formula I、Formula IA、Formula IB、Formula IC或Formula ID；其中R1、R2a、R2b、R3和R4如本文所定义。本发明的化合物可用于治疗疼痛、便秘以及受阿片类和ORL-1受体活性调节的其他疾病。
• THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
  申请人：Chen Zhengming

  公开号：US20100069437A1

  公开（公告）日：2010-03-18

  4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.

  本文介绍了4-四唑基-4-苯基哌啶化合物，包括含有效量的4-四唑基-4-苯基哌啶化合物的组合物，用于治疗或预防动物疼痛或腹泻的方法，包括向需要治疗的动物施用有效量的4-四唑基-4-苯基哌啶化合物，以及用于刺激细胞中的阿片受体功能的方法，包括用有效量的4-四唑基-4-苯基哌啶化合物接触能够表达阿片受体的细胞。
• Phenylpropionamide Compounds and the Use Thereof
  申请人：Zhou Xiaoming

  公开号：US20100234426A1

  公开（公告）日：2010-09-16

  The invention relates to phenylpropionamide compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A, B, R 1 , R 2 , R 3 , R 4 and R 5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the activation of opioid receptors, particularly μ-opioid receptors. Compounds of the present invention are especially useful for treating pain.

  本发明涉及公式（I）的苯丙酰胺化合物及其药学上可接受的盐、前药和溶剂化物，其中A、B、R1、R2、R3、R4和R5如规范中所述。本发明还涉及使用公式（I）的化合物来治疗、预防或缓解对阿片受体激活有反应的疾病，特别是μ-阿片受体。本发明的化合物对于治疗疼痛特别有用。
• Phenylpropionamide compounds and the use thereof
  申请人：Purdue Pharma LP

  公开号：EP2384768A1

  公开（公告）日：2011-11-09

  The invention relates to phenylpropionamide compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A, B, R1, R2, R3, R4 and R5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the activation of opioid receptors, particularly µ-opioid receptors. Compounds of the present invention are especially useful for treating pain.

  本发明涉及式 I 的苯基丙酰胺化合物： 及其药学上可接受的盐、原药和溶液，其中A、B、R1、R2、R3、R4和R5的定义如说明书所述。本发明还涉及使用式 I 的化合物治疗、预防或改善对阿片受体，特别是μ-阿片受体激活有反应的紊乱。本发明的化合物尤其适用于治疗疼痛。
• Process for the preparation of pimozide
  申请人：Institut Univ. de Ciència i Tecnologia, S.A.

  公开号：EP2357172A1

  公开（公告）日：2011-08-17

  The present invention relates to a process for the preparation of pimozide, characterized in that the reaction for obtaining said active ingredient is carried out in glycerol formal as an inert solvent at a pH higher than 4 and wherein said reaction is a SN2 nucleophilic substitution.

  本发明涉及一种制备匹莫齐特的工艺，其特征在于获得所述活性成分的反应是在 pH 值高于 4 的正式惰性溶剂甘油中进行的，其中所述反应为 SN2 亲核取代反应。