N-[3,5-bis(trifluoromethyl)phenyl]-N'-methylurea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3,5-bis(trifluoromethyl)phenyl]-N'-methylurea
• 英文别名: 1-[3,5-bis(trifluoromethyl)phenyl]-3-methylurea
• 化学式: C₁₀H₈F₆N₂O
• 分子量: 286.17
• InChiKey: HCFGXAMFTYDRCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] OXYCARBAMOYL COMPOUNDS AND THE USE THEREOF<br/>[FR] COMPOSÉS OXYCARBAMOYLE ET LEUR UTILISATION
  申请人：SHIONOGI & CO

  公开号：WO2009151152A1

  公开（公告）日：2009-12-17

  The invention relates to oxycarbamoyl compounds of Formula I: The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockadeof calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  这项发明涉及到化合物的氧羰基化合物的化学式I：该发明还涉及使用化合物的化学式I来治疗、预防或改善对钙通道阻滞有反应的疾病，尤其是N-型钙通道。本发明的化合物特别适用于治疗疼痛。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE OF SAME
  申请人：Shirai Junya

  公开号：US20110178060A1

  公开（公告）日：2011-07-21

  The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R 2 , R 3 , R 4a and R 4b are each independently a hydrogen atom, an optionally halogenated C 1-6 alkyl group or an optionally halogenated C 3-6 cycloalkyl group, or R 2 and R 3 are optionally bonded via an alkylene chain or an alkenylene chain, or R 4a and R 4b are optionally bonded via an alkylene chain or an alkenylene chain; R 1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.

  本发明涉及一种化合物，其表示为式： 其中，环A是一种含氮杂环；环B是一种芳香环，可选地具有取代基；环D是一种芳香环，可选地具有取代基；L是一个代表式为R2、R3、R4a和R4b的基团，其中R2、R3、R4a和R4b各自独立地是氢原子、可选卤代的C1-6烷基或可选卤代的C3-6环烷基，或者R2和R3通过烷基链或烯基链可选地连接，或者R4a和R4b通过烷基链或烯基链可选地连接；R1是氢原子或取代基；m和n各自独立地为0到5的整数；m+n是2到5的整数；以及为单键或双键，或其盐；等等。该化合物具有优良的缩氨酸受体拮抗作用，并可用作预防或治疗各种疾病的药剂，如下尿路疾病、消化道疾病、中枢神经系统疾病等。
• [EN] COMPOUND FOR ACTIVATING ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE<br/>[FR] COMPOSÉ POUR ACTIVER UNE PROTÉINE KINASE ACTIVÉE PAR UN MONOPHOSPHATE D'ADÉNOSINE<br/>[ZH] 活化腺苷单磷酸活化蛋白激酶之化合物
  申请人：FARMAR LICENSING CO LTD

  公开号：WO2018045969A1

  公开（公告）日：2018-03-15

  本发明揭示一种如结构式I之化合物，其作为腺苷单磷酸活化蛋白激酶之活化剂，而得以磷酸化活化腺苷单磷酸活化蛋白激酶，进而调控下游讯息传递路径，而可抑制肝癌细胞及乳癌细胞之生长分裂，亦可诱发脂肪细胞死亡；由此，本发明所揭示之化合物可应用于制备与腺苷单磷酸活化蛋白激酶相关之癌症及脂肪代谢疾病或症候群之医药组合物上，亦可用于治疗与腺苷单磷酸活化蛋白激酶相关之癌症及脂肪代谢疾病或症候群。
• FUNCTIONALIZED TRIPTYCENE POLYMERS AND THEIR USES
  申请人：Massachusetts Institute of Technology

  公开号：US20170022323A1

  公开（公告）日：2017-01-26

  Embodiments described herein relate to compositions including iptycene-based structures. Some embodiments provide compositions including polymers having a backbone comprising an iptycene-based compound. Some embodiments described herein provide compositions having enhanced properties such as enhanced porosity, increased glass transition temperatures, and/or improved solubility as compared to traditional poly(aryl ether)-based compounds or traditional iptycene-based compounds. In some cases, the compositions may include various aryl ether compounds such as an aryl ether ketone incorporated into the polymer backbone. Non-limiting examples of suitable aryl ether compounds include polyaylethersulfones, polyaryletherketones, polyetherimides, and polyphenylene ethers. The compositions described herein may be useful in a wide variety of applications, including structural materials, flexible composites, ion conductors, fuel cell membranes such as proton exchanging membranes, sensors, preconcentrators, absorbents, or the like.
• USRE48334E1
  申请人：——

  公开号：USRE48334E1

  公开（公告）日：2020-12-01