N-(4-chlorophenyl)-6-hydroxy-N-methyl-4-(trifluoromethyl)nicotinamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chlorophenyl)-6-hydroxy-N-methyl-4-(trifluoromethyl)nicotinamide
• 英文别名: N-(4-chlorophenyl)-N-methyl-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide
• 化学式: C₁₄H₁₀ClF₃N₂O₂
• 分子量: 330.69
• InChiKey: GEZIKCNMJOPGMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
  申请人：Mullan J. Michael

  公开号：US20070185130A1

  公开（公告）日：2007-08-09

  Provided are compounds useful for treating diseases associated with a cerebral accumulation of Alzheimer's amyloid, such as Alzheimer's disease. Also provided are methods for screening for such compounds, by measuring capacitative calcium entry in cells which optionally overexpress APP or a fragment thereof. Also provided are methods of treating or reducing the risk of developing β-amyloid production, β-amyloid deposition, β-amyloid neurotoxicity (including abnormal hyperphosphorylation of tau) and microgliosis associated with cerebral accumulation of Alzheimer's amyloid by administering therapeutically effective amounts of compounds which decrease β-amyloid production and capacitative calcium entry in cells. Further provided are methods for diagnosing diseases associated with cerebral accumulation of Alzheimer's amyloid in animals or humans by administering diagnostically effective amounts of compounds which inhibit capacitative calcium entry in cells.

  本发明提供了一些化合物，可用于治疗与阿尔茨海默病淀积相关的脑淀积性疾病，例如阿尔茨海默病。此外，本发明还提供了一种筛选此类化合物的方法，通过测量在细胞中的电容性钙离子进入，其中细胞可选择性地过度表达APP或其片段。本发明还提供了通过给予治疗有效量的化合物来治疗或减少β-淀粉样蛋白产生、β-淀粉样蛋白沉积、β-淀粉样蛋白神经毒性（包括tau异常高磷酸化）和与阿尔茨海默病淀积相关的微胶质细胞增生的方法，这些化合物可以减少β-淀粉样蛋白产生和细胞中的电容性钙离子进入。此外，本发明还提供了通过给动物或人类施用抑制细胞中电容性钙离子进入的化合物来诊断与阿尔茨海默病淀积相关的疾病的方法。