3-(4-tert-butylphenyl)phenylsulfonyl-L-phenylalanine(3-methoxyamidino)-4-(methylamidobuteryl)piperidide | 1042926-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-tert-butylphenyl)phenylsulfonyl-L-phenylalanine(3-methoxyamidino)-4-(methylamidobuteryl)piperidide
• 英文别名: 4-[1-[(2S)-2-[[3-(4-tert-butylphenyl)phenyl]sulfonylamino]-3-[3-[(Z)-N'-methoxycarbamimidoyl]phenyl]propanoyl]piperidin-4-yl]-N-methylbutanamide
• CAS: 1042926-87-3
• 化学式: C₃₇H₄₉N₅O₅S
• 分子量: 675.893
• InChiKey: KQMRCXHXFZUJGN-XIFFEERXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  48
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  152
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS
  申请人：Steinmetzer Torsten

  公开号：US20100305090A1

  公开（公告）日：2010-12-02

  The invention relates to meta-substituted phenyl sulfonyl amides of secondary amino acid amides according to the general formula (I), (II), or (III), the production thereof, and the use thereof as matriptase inhibitors, in particular the use thereof as drugs for inhibiting tumor growth and/or metastasization.

  该发明涉及通式（I）、（II）或（III）的次级氨基酸酰胺的亚苯基磺酰胺，其制备方法以及其作为matriptase抑制剂的用途，特别是其作为抑制肿瘤生长和/或转移的药物的用途。
• Matriptase inhibitors and uses thereof against orthomyxoviridae infections
  申请人：Socpra Sciences Sante Et Humaines S.E.C.

  公开号：US10208308B2

  公开（公告）日：2019-02-19

  The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flue infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and prevention orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.

  本发明提供了用于治疗和预防正粘病毒感染（如絮状病毒感染）的matriptase抑制剂和组合物。本发明还提供了用于抑制 matriptase 的新型化合物、组合物、使用方法、用途及其试剂盒。此类化合物可用于治疗和预防正粘病毒感染，如流感感染，以及抑制肿瘤的生长、恶化和/或转移。
• META-SUBSTITUIERTE PHENYLSULFONYLAMIDE SEKUNDÄRER AMINOSÄUREAMIDE ALS HEMMSTOFFE DER MATRIPTASE ZUR HEMMUNG DES TUMORWACHSTUMS UND/ODER DER METASTASIERUNG VON TUMOREN
  申请人：The Medicines Company (Leipzig) GmbH

  公开号：EP2132174B1

  公开（公告）日：2012-02-01
• MATRIPTASE INHIBITORS AND USES THEREOF AGAINST ORTHOMYXOVIRIDAE INFECTIONS
  申请人：Socpra Sciences Sante Et Humaines S.E.C.

  公开号：US20170314023A1

  公开（公告）日：2017-11-02

  The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flue infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and prevention orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.
• US8569313B2
  申请人：——

  公开号：US8569313B2

  公开（公告）日：2013-10-29