1-[3,5-Bis(trifluoromethyl)phenyl]-3-tert-butylurea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[3,5-Bis(trifluoromethyl)phenyl]-3-tert-butylurea
• 化学式: C₁₃H₁₄F₆N₂O
• 分子量: 328.25
• InChiKey: IJLOFHQDALMYOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST
  申请人：Farmar Licensing Co., Ltd.

  公开号：US20190194142A1

  公开（公告）日：2019-06-27

  The present invention discloses a compound of the formula (I), which acts as an agonist of adenosine monophosphate-activated protein kinase, which induce phosphorylation and activation of AMPKα, thereby further regulating downstream signaling pathways, inhibiting growth and proliferation of liver cancer cells and breast cancer cells, and also inducing apoptosis of adipocytes. Therefore, the compound provided by the present invention can be utilised for treatment and preparation of pharmaceutical composition for cancer, and lipid metabolism-related diseases or syndromes mediated by AMPK.

  本发明公开了一种化合物(I)的公式，该化合物作为腺苷单磷酸激活蛋白激酶的激动剂，诱导AMPKα的磷酸化和激活，从而进一步调节下游信号通路，抑制肝癌细胞和乳腺癌细胞的生长和增殖，并诱导脂肪细胞凋亡。因此，本发明提供的化合物可用于癌症的治疗和制备药物组合物，以及由AMPK介导的脂质代谢相关疾病或综合征。
• Adenosine monophosphate-activated protein kinase agonist
  申请人：NATIONAL YANG-MING UNIVERSITY

  公开号：US10793527B2

  公开（公告）日：2020-10-06

  The present invention discloses a compound of the formula (I), which acts as an agonist of adenosine monophosphate-activated protein kinase, which induce phosphorylation and activation of AMPKα, thereby further regulating downstream signaling pathways, inhibiting growth and proliferation of liver cancer cells and breast cancer cells, and also inducing apoptosis of adipocytes. Therefore, the compound provided by the present invention can be utilised for treatment and preparation of pharmaceutical composition for cancer, and lipid metabolism-related diseases or syndromes mediated by AMPK.

  本发明公开了一种式（I）化合物，它作为单磷酸腺苷激活蛋白激酶的激动剂，可诱导AMPKα磷酸化和活化，从而进一步调节下游信号通路，抑制肝癌细胞和乳腺癌细胞的生长和增殖，还可诱导脂肪细胞凋亡。因此，本发明提供的化合物可用于治疗和制备 AMPK 介导的癌症和脂质代谢相关疾病或综合征的药物组合物。