4-((E)-2-[4-(Diethylamino)phenyl]ethenyl)-1-[3-(triethylammonio)propyl]pyridinium dibromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-((E)-2-[4-(Diethylamino)phenyl]ethenyl)-1-[3-(triethylammonio)propyl]pyridinium dibromide
• 英文别名: 3-[4-[(E)-2-[4-(diethylamino)phenyl]ethenyl]pyridin-1-ium-1-yl]propyl-triethylazanium;dibromide
• 化学式: C26H41Br2N3
• 分子量: 555.4
• InChiKey: HLNKJDYNEWLULB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.73
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Lipophilic dye-based FRET assays for clostridial toxin activity
  申请人：ALLERGAN, INC.

  公开号：EP2293064A1

  公开（公告）日：2011-03-09

  Compositions useful for detecting Clostridial toxin activity comprising a cell that comprises a membrane-associated Clostridial toxin substrate comprising a first member of a fluorescence resonance energy transfer pair; and a Clostridial toxin recognition sequence including a cleavage site; and a membrane-associated second member of the FRET pair and methods useful for determining Clostridial toxin activity using such Clostridial toxin substrates.

  用于检测梭状芽孢杆菌毒素活性的组合物，该组合物包含一个细胞，该细胞包含与膜结合的梭状芽孢杆菌毒素底物，该底物包含荧光共振能量转移对的第一位成员；和包括裂解位点的梭状芽孢杆菌毒素识别序列；以及与膜结合的荧光共振能量转移对的第二位成员，以及使用这种梭状芽孢杆菌毒素底物确定梭状芽孢杆菌毒素活性的方法。
• Characterization of subvisible particles using a particle analyzer
  申请人：Baxalta Incorporated

  公开号：US10274500B2

  公开（公告）日：2019-04-30

  The present specification discloses methods of characterizing a population of particles using a particle analyzer. Particles may be characterized by size, absolute number, whether the particle is non-proteinaceous or proteinaceous, whether a proteinaceous particle has or lacks a certain physical property, or any combination thereof.

  本说明书公开了使用颗粒分析仪表征颗粒群的方法。颗粒可以通过大小、绝对数量、颗粒是非蛋白质还是蛋白质、蛋白质颗粒是否具有或缺乏某种物理特性或它们的任意组合来表征。
• Assay for compounds that protect against sensory hair cell death and compounds identified by same
  申请人：Ou C. Henry

  公开号：US20060188445A1

  公开（公告）日：2006-08-24

  The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.

  本发明提供了鉴定可防止由一种或多种有害刺激诱发的耳毒性的化合物的方法，以及用本筛选方法鉴定的化合物治疗个体的方法。本发明还提供了经证实具有耳保护作用的化合物。
• LIPOPHILIC DYE-BASED FRET ASSAYS FOR CLOSTRIDIAL TOXIN ACTIVITY
  申请人：ALLERGAN, INC.

  公开号：EP1869459B1

  公开（公告）日：2010-06-09
• Lipophilic Dye-Based Fret Assays for Clostridal Toxin Activity
  申请人：Fernandez-Salas Ester

  公开号：US20080160561A1

  公开（公告）日：2008-07-03

  Compositions useful for detecting Clostridial toxin activity comprising a cell that comprises a membrane-associated Clostridial toxin substrate comprising a first member of a fluorescence resonance energy transfer pair; and a Clostridial toxin recognition sequence including a cleavage site; and a membrane-associated second member of the FRET pair and methods useful for determining Clostridial toxin activity using such Clostridial toxin substrates.