p-C2H5(CH3)CHCH2C6H4COCl | 62618-35-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-C2H5(CH3)CHCH2C6H4COCl
• 英文别名: (+)-p-(2-METHYLBUTYL)BENZOYL CHLORIDE；4-(2-methylbutyl)benzoyl chloride
• CAS: 62618-35-3
• 化学式: C₁₂H₁₅ClO
• 分子量: 210.704
• InChiKey: JTFWIFQALWOEGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4-二羟基苯甲醛 、 p-C2H5(CH3)CHCH2C6H4COCl 生成 (4-formyl-3-hydroxyphenyl) 4-[(2R)-2-methylbutyl]benzoate
  参考文献：
  名称：

  SIONODZAKI, JOSITAKEH

  摘要：

  DOI：

文献信息

• Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides
  申请人：ELI LILLY AND COMPANY

  公开号：EP0825164A2

  公开（公告）日：1998-02-25

  This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.

  这项发明涉及一种用于制备酰胺、碳酸酯和磺酰胺组合库的新型溶液相过程。这些库在药物发现中具有实用价值，并用于形成新型检测套件的微孔板组件。
• [EN] NEW FYN AND VEGFR2 KINASE INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE KINASES FYN ET VEGFR2
  申请人：ROTTAPHARM BIOTECH SRL

  公开号：WO2021115560A1

  公开（公告）日：2021-06-17

  The invention relates to a N-phenylcarbamoyl compound of Formula (I) or a pharmaceutically acceptable salt thereof for use in the inhibition of at least one of tyrosine kinase selected from Fyn and VEGFR2 in the treatment of diseases and disorders involved with one or both kinases. (Formula)

  该发明涉及一种化合物N-苯基甲酰胺（I）的使用或其在治疗涉及Fyn和VEGFR2中至少一种酪氨酸激酶抑制剂中的药用盐，用于治疗与这两种激酶中至少一种相关的疾病和疾病。
• Liquid crystalline ester compounds and mixtures thereof
  申请人：Chisso Corporation

  公开号：US04834907A1

  公开（公告）日：1989-05-30

  Novel chiral smectic liquid crystalline ester compounds having a superior stability and exhibiting a high response rate when used in the form of display elements and chiral smectic mixtures containing at least one of these compounds are provided, which compounds are expressed by the formula ##STR1## wherein n is an integer of 2 to 16; l is 0, 1 or 2; m is 1 or 2 under the condition of l+m.gtoreq.2; X represents methylene group --CH.sub.2 -- or single bond when l is zero, methylene group --CH.sub.2 -- or ether linkage --O-- when l=1 or ether linkage --O-- when l=2; and Y represents R, OR, --COR, --OCOR, --OCOOR or --COOR wherein R throughout represents an alkyl group of 1 to 18 carbon atoms; and asterisk * shows an optically active carbon atom.

  提供了具有优越稳定性并在显示元件中以及手性液晶混合物中使用时表现出高响应速率的新型手性液晶酯化合物，其中这些化合物由公式##STR1##表示，其中n是2到16的整数；l为0、1或2；在l+m≥2的条件下，m为1或2；当l为零时，X表示亚甲基基--CH.sub.2--或单键，当l=1时，X表示亚甲基基--CH.sub.2--或醚键--O--，当l=2时，X表示醚键--O--；Y表示R、OR、--COR、--OCOR、--OCOOR或--COOR，其中R表示1到18个碳原子的烷基；星号*表示一个光学活性碳原子。
• Fluoroalkane derivative, its composition and liquid crystal device using same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0267585A2

  公开（公告）日：1988-05-18

  A liquid crystal composition, comprising: at least one optically active mesomorphic compound having an asymmetric carbon atom to which a fluorine atom is directly bonded, and at least one mesomorphic compound having an optically active group represented by the following formula (1): wherein R1 denotes a linear or branched alkyl group having 1 - 18 carbon atoms, x is 0 or 1, y is an integer of 0 - 8, and C* denotes an asymmetric carbon atom.

  一种液晶组合物，包括：至少一种具有光学活性的间位化合物，该化合物具有与氟原子直接键合的不对称碳原子，以及至少一种具有下式（1）所代表的光学活性基团的间位化合物：其中 R1 表示具有 1 - 18 个碳原子的直链或支链烷基，x 为 0 或 1，y 为 0 - 8 的整数，C* 表示不对称碳原子。
• Mesomorphic compound and liquid crystal composition containing same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0285141A1

  公开（公告）日：1988-10-05

  An optically active mesomorphic compound is represented by the following formula (I): wherein R₁ and R₂ are respectively an alkyl group having 1 to 16 carbon atoms, and C* denotes an asymmetric carbon atom. The mesomorphic compound has a fluorine atom directly connected to the asymmetric carbon atom and is effectively used as a liquid crystal component providing an increased spontaneous polarization and an improved responsive­ness.

  一种具有光学活性的间位化合物由下式（I）表示： 其中 R₁ 和 R₂ 分别为具有 1 至 16 个碳原子的烷基，C* 表示不对称碳原子。介形化合物中的氟原子与不对称碳原子直接相连，可有效用作液晶成分，从而提高自发极化和响应速度。