(4-chlorophenyl)-[4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]methanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-chlorophenyl)-[4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]methanone
• 化学式: C₂₁H₁₅ClF₃NOS
• 分子量: 421.9
• InChiKey: CWEZGURFZHADHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  48.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE<br/>[FR] DERIVES DE 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE, LEUR PREPARATION ET LEUR UTILISATION
  申请人：NOVO NORDISK A/S

  公开号：WO1998040385A1

  公开（公告）日：1998-09-17

  (EN) 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine derivative modulate the activity of molecules with glucose-6-phosphate recognition units, including glucose-6-phosphatases (G-6-Pases) in $i(in vitro ) systems, microorganisms, eukaryotic cells, whole animals and human beings, and are useful in the treatment of diseases related to glucose metabolic pathways.(FR) Les dérivés de 4,5,6,7-tétrahydro-thiéno[3,2-c]pyridine modulent l'activité de molécules à l'aide d'unités de reconnaissance glucose-6-phosphate, notamment des glucose-6-phosphatases dans des systèmes $i(in vitro), des micro-organismes, des cellules eucaryotes, des animaux entiers et des humains, et sont utiles dans le traitement de maladies associées aux voies métaboliques du glucose.

  (EN) 4,5,6,7-四氢-3,2-c-位吡咯四氢并噻吩的衍生物调节了含有葡萄糖六磷酸识别单元的分子活性，包括体外实验( $i(in vitro ) $)、微生物、真核细胞、完整动物和人类，对治疗与葡萄糖代谢途径相关的疾病有 usefulness。 (FR) Les dérivés de 4,5,6,7-四氢-3,2-c-位吡咯四氢并噻吩 modulent l'activité de molécules au moyen d'unités de reconnaissance de glucose six-phosphaté, notamment de glucose six-phosphatases dans des $systèmes (i( in vitro )), des micro-organismes, des cellules eucaryotes, des animaux entiers et des humains, et sont utiles dans le traitement des maladies liées aux voies métaboliques du glucose.
• 4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
  申请人：NOVO NORDISK A/S

  公开号：EP0973778A1

  公开（公告）日：2000-01-26
• [EN] PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF DISEASED TISSUES<br/>[FR] COMPOSITIONS PHARMACEUTIQUES DESTINEES AU TRAITEMENT DES TISSUS MALADES
  申请人：LEE CLARENCE C

  公开号：WO2000040269A2

  公开（公告）日：2000-07-13

  A method to treat diseased tissue is provided where a cytotoxic compound is administered to a patient in need of treatment in combination with an immunostimulant. Diseased cells and/or infectious microbes/viruses are killed by the cytotoxic compound in the presence of the immunostimulant. The cell components including cellular contents and cell membrane fragments are presented by the immunostimulant to the host animal as antigens to stimulate the immune responses toward other diseased cells of the same type(s), that either remain in the vicinity or reside in distant tissues or organs. The cytotoxic molecule and immunostimulant are preferably applied locally at high concentrations, either sequentially or, preferably, simultaneously. For example, the composition can be administered directly to a target cancer. The composition can be prepared in various forms, such as a paste, a time release molded solid shape, a solution, a mixture with emulsifier, etc. Alternatively, the cytotoxic molecule and immunostimulant are applied in sequence.