Isopropyl 4'-amino-[1,1'-biphenyl]-3-carboxylate | 728918-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Isopropyl 4'-amino-[1,1'-biphenyl]-3-carboxylate
• 英文别名: propan-2-yl 3-(4-aminophenyl)benzoate
• CAS: 728918-85-2
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.31
• InChiKey: DPKYJGXTSUUQPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• ANTIPROLIFERATIVE COMPOUNDS AND CONJUGATES MADE THEREFROM
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20180110873A1

  公开（公告）日：2018-04-26

  A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.

  一种能够抑制细胞增殖的化合物，其结构符合以下公式（I） 其中公式（I）中的变量如规范中所定义。这些化合物可用作抗癌药物，特别是在抗体药物结合物中。
• Antiproliferative compounds and conjugates made therefrom
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10398783B2

  公开（公告）日：2019-09-03

  A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.

  一种能够抑制细胞增殖的化合物，其结构如式 (I) 所示 其中式（I）中的变量如说明书中所定义。这类化合物可用作抗癌剂，特别是抗体-药物共轭物。
• [EN] CONDENSED BENZODIAZEPINE DERIVATIVES AND CONJUGATES MADE THEREFROM<br/>[FR] DÉRIVÉS DE BENZODIAZÉPINE CONDENSÉS ET CONJUGUÉS FABRIQUÉS À PARTIR DE CEUX-CI
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2018075842A1

  公开（公告）日：2018-04-26

  A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.