3-Chloro-2-fluorobenzylmethylsulfone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Chloro-2-fluorobenzylmethylsulfone
• 英文别名: 1-chloro-2-fluoro-3-(methylsulfonylmethyl)benzene
• 化学式: C₈H₈ClFO₂S
• 分子量: 222.66
• InChiKey: ONXKBOQQVUGJBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• CATHEPSIN INHIBITORS FOR THE TREATMENT OF BONE CANCER AND BONE CANCER PAIN
  申请人：Booth Robert

  公开号：US20120282267A1

  公开（公告）日：2012-11-08

  The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer.

  本发明涉及使用抑制蛋白酶半胱氨酸蛋白酶的化合物的方法，特别是用于治疗骨癌的卡特普辛S和K以及可选地进一步的卡特普辛B和/或L。本发明涉及含有这些化合物的药物组合物，用于治疗骨癌和骨癌疼痛，尤其是与转移有关的疼痛。单一化合物可用于缓解疼痛、骨折伤，同时减少肿瘤生长、转移风险和/或癌症的侵袭性。
• Novel compounds and compositions as cathepsin inhibitors
  申请人：——

  公开号：US20040147503A1

  公开（公告）日：2004-07-29

  The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  本发明涉及新型选择性卡特普西林S抑制剂，其药学上可接受的盐和N-氧化物，其作为治疗剂的用途以及其制备方法。
• Haloalkyl Containing Compounds as Cysteine Protease Inhibitors
  申请人：Setti Eduardo L.

  公开号：US20090023781A1

  公开（公告）日：2009-01-22

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及一种抑制半胱氨酸蛋白酶的化合物，特别是cathepsins B、K、L、F和S，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的制药组合物和制备它们的过程。
• Novel Compounds and Compositions as Cathepsin Inhibitors
  申请人：Patterson W. John

  公开号：US20070232654A1

  公开（公告）日：2007-10-04

  The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  本发明涉及新型选择性卡特普西林S抑制剂，其药学上可接受的盐和N-氧化物，以及它们作为治疗剂的用途和制备方法。
• Alpha ketoamide compounds as cysteine protease inhibitors
  申请人：Graupe Michael

  公开号：US20070021353A1

  公开（公告）日：2007-01-25

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及一种抑制半胱氨酸蛋白酶的化合物，特别是对卡特普西蛋白B、K、L、F和S的抑制剂，因此可以用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的制药组合物和制备它们的方法。