4-(4-(Didecylamino)styryl)-N-methylpyridinium iodide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-(Didecylamino)styryl)-N-methylpyridinium iodide
• 英文别名: N,N-didecyl-4-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]aniline;iodide
• 化学式: C34H55IN2
• 分子量: 618.7
• InChiKey: PPAYPDQCRKDOKR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  6.77
• 重原子数：
  37
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Sensitized online BOLD-MRI imaging method
  申请人：YEDA RESEARCH AND DEVELOPMENT CO., LTD.

  公开号：EP2401962A1

  公开（公告）日：2012-01-04

  An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imaging (MRI) method for functional clinical guidance or monitoring a therapeutic modality involving treatment by a sensitizer which, upon excitation by the appropriate sensitizing radiation, initiates local oxygen consumption, comprising: (i) generating a BOLD-weighted MR-image of the target region of interest within the patient's body (time to); (ii) administering said sensitizer to the patient; (iii) irradiating the target region while the patient is subjected to continuous MR imaging; (iv) generating a sole or a plurality of T2* weighted sequential BOLD MR-images during and/or after irradiation (time t); (v) processing the data generated at time to and time t and generating a color-coded difference or ratio map on a pixel by pixel basis; and (vi) analyzing the processed data. The method is preferably applied to photodynamic therapy (PDT).

  一种在线血液氧合水平依赖性（BOLD）-磁共振成像（MRI）方法，用于功能性临床指导或监测涉及增敏剂治疗的治疗方式，该增敏剂在适当的增敏辐射激发下启动局部氧消耗，包括：(i) 生成患者体内感兴趣的目标区域的 BOLD 加权磁共振图像（时间至）；(ii) 给患者施用所述增敏剂；(iii) 对患者体内感兴趣的目标区域进行照射（时间至）：(i) 生成患者体内感兴趣靶区的 BOLD 加权 MR 图像（时间至）；(ii) 给患者注射所述增敏剂；(iii) 在患者接受连续 MR 成像的同时照射靶区；(iv) 在照射期间和/或照射后（时间 t）生成唯一或多个 T2* 加权连续 BOLD MR 图像；(v) 处理在时间 to 和时间 t 生成的数据，并按像素生成彩色编码差异或比率图；以及 (vi) 分析处理后的数据。该方法最好应用于光动力疗法（PDT）。
• KIT FOR DETECTING VIRUS
  申请人：Huvet Bio, Inc.

  公开号：EP3244210A1

  公开（公告）日：2017-11-15

  The present invention relates to a kit for detecting a virus, a composition for detecting a virus and a method for detecting a virus. According to the present invention, viruses may be detected with high efficiency at low cost within a short period of time.

  本发明涉及一种检测病毒的试剂盒、一种检测病毒的组合物和一种检测病毒的方法。根据本发明，可在短时间内以低成本高效率地检测病毒。
• SEMAPHORIN 3A NEURODEGENERATION MODULATORS, COMPOSITIONS AND USES THEREOF
  申请人：Consejo Superior de Investigaciones Científicas (CSIC)

  公开号：EP3822283A1

  公开（公告）日：2021-05-19

  Various neurodegenerative processes are entrained and maintained by signaling through Semaphorin 3A leading to apoptosis and loss of neuronal cells and tissues. Examples of such processes include glaucoma of the eye, stroke, ischemia of the optic nerve and other major nerves, retinal detachment and trauma. Small molecules in solution or in slow release systems are demonstrated to alleviate loss of retinal ganglial cells in models of CNS injury to the eye.

  各种神经退行性病变的过程都是通过闪烁素 3A 发出信号，导致神经细胞和组织凋亡和丧失。此类过程的例子包括青光眼、中风、视神经和其他主要神经缺血、视网膜脱落和创伤。在中枢神经系统对眼睛的损伤模型中，溶液或缓释系统中的小分子已被证明可减轻视网膜神经节细胞的损失。
• Intra-operative head and neck nerve mapping
  申请人：Mangat Gurpreet

  公开号：US10231624B2

  公开（公告）日：2019-03-19

  The invention provides both systems and kits for medical imaging of nerves in the head and neck of a subject.

  本发明提供了对受试者头颈部神经进行医学成像的系统和套件。
• Use of copolymer 1 and related peptides and polypeptides and T cells treated therewith for neuroprotective therapy
  申请人：——

  公开号：US20020037848A1

  公开（公告）日：2002-03-28

  Methods are provided for treating injury to or disease of the central or peripheral nervous system. In one embodiment, treatment is effected by administering activated T cells that recognize an antigen of Cop 1 or a Cop 1-related peptide or polypeptide to promote nerve regeneration or to prevent or inhibit neuronal degeneration within the nervous system. In another embodiment, treatment involves administering Cop 1 or a Cop 1-related peptide or polypeptide to promote nerve regeneration or to prevent or inhibit neuronal degeneration in the nervous system, either the central nervous system or the peripheral nervous system. The activated T cells, which have been activated by the presence of Cop 1 or a Cop 1-related peptide or polypeptide, can be administered alone or in combination with Cop 1 or a Cop 1-related peptide or polypeptide.

  本文提供了治疗中枢或周围神经系统损伤或疾病的方法。在一个实施方案中，治疗方法是给识别 Cop 1 抗原或 Cop 1 相关肽或多肽的活化 T 细胞用药，以促进神经再生或防止或抑制神经系统内的神经元变性。在另一个实施方案中，治疗涉及施用Cop 1或Cop 1相关肽或多肽，以促进神经再生或预防或抑制神经系统（中枢神经系统或外周神经系统）中的神经元变性。活化的 T 细胞由于 Cop 1 或与 Cop 1 相关的肽或多肽的存在而被激活，可以单独给药，也可以与 Cop 1 或与 Cop 1 相关的肽或多肽联合给药。