(4-Aminophenyl)(4-cyclohexylpiperazino)methanone | 885949-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Aminophenyl)(4-cyclohexylpiperazino)methanone
• 英文别名: (4-aminophenyl)-(4-cyclohexylpiperazin-1-yl)methanone
• CAS: 885949-70-2
• 化学式: C₁₇H₂₅N₃O
• 分子量: 287.4
• InChiKey: ISEWARYCFRTPRD-UHFFFAOYSA-N

物化性质

• 熔点：
  134

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  49.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

文献信息

• PYRIMIDINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS JAK2 KINASE INHIBITORS
  申请人：Vankayalapati Hariprasad

  公开号：US20080214558A1

  公开（公告）日：2008-09-04

  Pyrimidine-2,4-diamines derivatives having activity as JAK2 kinase inhibitors are disclosed, as well as pharmaceutical compositions and methods for using the same in the treatment of cancer and other JAK2 kinase-associated conditions.

  翻译结果为：披露了具有JAK2激酶抑制活性的嘧啶-2,4-二胺衍生物，以及用于治疗癌症和其他与JAK2激酶相关的条件的药物组合物和方法。
• Pyrimidine-2, 4-diamine JAK2 Kinase inhibiting anti-inflammation use
  申请人：Hwang Soo-In

  公开号：US20100029675A1

  公开（公告）日：2010-02-04

  A method of treatment or prevention of Castleman's disease, atherosclerosis, coronary artery disease, peripheral edema, peripheral vascular disease, glaucoma, and wet or dry age-related macular degeneration (AMD), asthma; chronic bronchitis; chronic obstructive pulmonary disease; adult respiratory distress syndrome; infant respiratory distress syndrome; cough; chronic obstructive pulmonary disease in animals; adult respiratory distress syndrome; ulcerative colitis; Crohn's disease; hypersecretion of gastric acid; bacterial, fungal, or viral induced sepsis or septic shock; endotoxic shock; laminitis or colic in horses; spinal cord trauma; head injury; neurogenic inflammation; pain; reperfusion injury of the brain; psoriatic arthritis; rheumatoid arthritis; alkylosing spondylitis; osteoarthritis; inflammation; or cytokine-mediated chronic tissue degeneration comprises the step of administering a therapeutically effective amount, or a prophylactically effective amount, of a compound having the following structure (I):

  一种治疗或预防卡斯尔曼病、动脉粥样硬化、冠状动脉疾病、周围水肿、周围血管疾病、青光眼、湿性或干性老年性黄斑变性（AMD）、哮喘；慢性支气管炎；慢性阻塞性肺病；成人呼吸窘迫综合征；婴儿呼吸窘迫综合征；咳嗽；动物的慢性阻塞性肺病；成人呼吸窘迫综合征；溃疡性结肠炎；克罗恩病；胃酸过分分泌；细菌、真菌或病毒诱导的败血症或感染性休克；内毒素性休克；马的蹄叶炎或肠绞痛；脊髓创伤；头部损伤；神经源性炎症；疼痛；脑再灌注损伤；银屑病性关节炎；类风湿性关节炎；强直性脊柱炎；骨关节炎；炎症；或细胞因子介导的慢性组织退化的治疗方法包括给予具有以下结构（I）的化合物的治疗有效量或预防有效量。
• PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS
  申请人：Singh Rajinder

  公开号：US20120088768A1

  公开（公告）日：2012-04-12

  Pinane-substituted pyrimidinediamine derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the derivatives in treating diseases or conditions associated with Axl catalytic activity are also disclosed.
• [EN] KINASE INHIBITORS AND THEIR USES<br/>[FR] INHIBITEURS DE KINASE ET LEURS UTILISATIONS
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2007070872A1

  公开（公告）日：2007-06-21

  [EN] The present disclosure provides compounds that inhibit protein kinases, such as JAK, AxI, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein kinase and treat and/or prevent diseases associated with inappropriate kinase activity.
  [FR] La présente invention concerne des composés inhibiteurs de protéines kinases, telles que JAK, AxI ou Syk kinases, des compositions contenant ces composés et des procédés d'utilisation de ces composés pour inhiber des protéines kinases et traiter et/ou prévenir des maladies associées à une activité kinase inappropriée.
• [EN] PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIMIDINEDIAMINE SUBSTITUÉS PAR DU PINANE, UTILES EN TANT QU'INHIBITEURS DE AXL
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2008045978A1

  公开（公告）日：2008-04-17

  [EN] Pinane-substituted pyrimidipediamine derivatives derivatives, for example, compounds of formula (Ia): wherein: n is 0 to 7; m is 0 to 2; R¹. R². R⁴ and R⁵ are each independently hydrogen, alkyl, aryl, aralkyl, cycloalkyl. cycloalkylalkyl. -R¹⁴-OR¹⁵. -C(O)R¹⁵ Or -C(O)N(R¹¹JR¹²; or R⁴ and R⁵, together with the nitrogen to which they are attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl; R⁶. R⁷ and R⁸ are each independently alkyl, haloalkyl, or -R^{1 3}-
  [FR] L'invention concerne des dérivés de pyrimidinediamine substitués par du pinane et des compositions pharmaceutiques contenant les dérivés, lesdits dérivés étant utiles pour l'inhibition de l'activité du récepteur de protéine tyrosine kinase Axl. L'invention concerne également des procédés d'utilisation des dérivés pour le traitement de maladies ou de troubles associés avec l'activité catalytique Axl.