2-(4-Chlorophenyl)-2-{6-[(4-chlorophenyl)sulfanyl]-3-pyridazinyl}acetamide

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-(4-Chlorophenyl)-2-{6-[(4-chlorophenyl)sulfanyl]-3-pyridazinyl}acetamide
• 英文别名: 2-(4-chlorophenyl)-2-[6-(4-chlorophenyl)sulfanylpyridazin-3-yl]acetamide
• 化学式: C₁₈H₁₃Cl₂N₃OS
• 分子量: 390.3
• InChiKey: ZUBVWWQYGHUYKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  94.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Selective high-affinity polydentate ligands and methods of making such
  申请人：LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

  公开号：US10292992B2

  公开（公告）日：2019-05-21

  This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

  本发明提供了新型多齿选择性高亲和性配体（SHALs），可以以类似于使用抗体的方式用于各种应用。SHALs 通常由多个配体组成，每个配体与目标分子的不同区域结合。配体直接连接或通过连接体连接，从而形成多齿分子，通常能以高选择性和高热敏性结合目标分子。
• Selective high affinity polydentate ligands and methods of making such
  申请人：DeNardo Sally

  公开号：US20060084115A1

  公开（公告）日：2006-04-20

  This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

  本发明提供了新型多齿选择性高亲和性配体（SHALs），可以以类似于使用抗体的方式用于各种应用。SHALs 通常由多个配体组成，每个配体与目标分子的不同区域结合。配体直接连接或通过连接体连接，从而形成多齿分子，通常能以高选择性和高热敏性结合目标分子。
• SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP2268654B1

  公开（公告）日：2017-01-25
• Selective High-Affinity Polydentate Ligands and Methods of Making Such
  申请人：DeNardo Sally

  公开号：US20100184702A1

  公开（公告）日：2010-07-22

  This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
• VACCINE DEVELOPMENT METHODOLOGY BASED ON AN ADHESION MOLECULE
  申请人：MatSfide, Inc.

  公开号：US20210106677A1

  公开（公告）日：2021-04-15

  A method of eliciting immune responses using synthetic antigens involves generating a substitute antigen configured for a foreign molecule, generating a synthetic high affinity ligand molecule (SHAL) comprising at least one ligand configured to bind to an antigen presenting cell (APC) and at least one ligand specifically configured to bind with the substitute antigen, combining the SHAL with the substitute antigen through a chemical reaction forming an antigen presenting complex, introducing the antigen presenting complex to a user without an immune response to the foreign molecule.