1-Piperidin-1-yl-3-(4-propylphenoxy)propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Piperidin-1-yl-3-(4-propylphenoxy)propan-2-ol
• 化学式: C₁₇H₂₇NO₂
• 分子量: 277.4
• InChiKey: OSMSNAJZFCSFBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• High Throughput Assay for Discovering New Inhibitors of the GIRK1/4 Channel
  申请人：Walsh Kenneth B.

  公开号：US20110281278A1

  公开（公告）日：2011-11-17

  In certain embodiments of the present disclosure, a method for determining an inhibitor of acetylcholine-activated potassium channel is described. The method includes incubating a cardiac cell in a solution comprising a test compound. The method further includes adding a muscarine (M2) receptor agonist to the cardiac cell in the solution and monitoring the cardiac cell for a change in membrane potential. A statistically insignificant change in the membrane potential following addition of the muscarine (M2) receptor to the solution signifies that the test compound is a K + channel blocker that inhibits opening of the acetylcholine-activated potassium channel.
• US8323911B2
  申请人：——

  公开号：US8323911B2

  公开（公告）日：2012-12-04