9-Hydroxy-2-(2-methoxyethyl)-1,8-dioxo-3,4-dihydropyrido[1,2-a]pyrazine-7-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 9-Hydroxy-2-(2-methoxyethyl)-1,8-dioxo-3,4-dihydropyrido[1,2-a]pyrazine-7-carboxylic acid
• 英文别名: 9-hydroxy-2-(2-methoxyethyl)-1,8-dioxo-3,4-dihydropyrido[1,2-a]pyrazine-7-carboxylic acid
• 化学式: C₁₂H₁₄N₂O₆
• 分子量: 282.25
• InChiKey: IKYGQTLDZLNFFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE
  申请人：National University Corporation Hokkaido University

  公开号：EP3815689A1

  公开（公告）日：2021-05-05

  The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound. An arenavirus proliferation inhibitor comprising a compound represented by Formula (I) or a prodrug thereof or a pharmaceutically acceptable salt thereof: (wherein R1 is carboxy, or the like; A3 is CR2 or N; R2 is a hydrogen atom, halogen, hydroxy, or the like; R3 is a hydrogen atom, hydroxy, carboxy, cyano, formyl, alkyl optionally substituted with Substituent group F, or the like; either A1 or A2 is CR5R6, and the other is NR7, or A1 is CR8R9, and A2 is CR10R11; and R5, R6, R7, R8, R9, R10, and R11 are each independently a hydrogen atom, carboxy, cyano, alkyl optionally substituted with Substituent group F, or the like).

  本发明提供了一种具有抗病毒活性的化合物，尤其是具有抑制禽流感病毒增殖活性的化合物，和/或包含该化合物的药物。更优选地，本发明提供了一种化合物，该化合物对旧大陆病毒（如卢纳病毒、拉萨病毒和淋巴细胞色素膜炎病毒）和/或新大陆病毒（如朱宁病毒）具有增殖抑制活性，和/或包含该化合物的药物。 一种由式（I）代表的化合物或其原药或其药学上可接受的盐组成的腺病毒增殖抑制剂： (其中 R1 是羧基或类似物；A3 是 CR2 或 N；R2 是氢原子、卤素、羟基或类似物；R3 是氢原子、羟基、羧基、氰基、甲酰基、任选被取代基 F 取代的烷基或类似物；A1 或 A2 是 CR5R6，另一个是 NR7，或 A1 是 CR8R9，A2 是 CR10R11；以及 R5、R6、R7、R8、R9、R10 和 R11 各自独立地是氢原子、羧基、氰基、任选被取代基 F 取代的烷基或类似基团）。
• SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：EP2444400B1

  公开（公告）日：2018-03-28
• SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG
  申请人：Shionogi & Co., Ltd.

  公开号：EP2620436B1

  公开（公告）日：2018-05-09