1-[2-(1-methylethenyl)phenyl]propan-2-ol | 1259071-40-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-(1-methylethenyl)phenyl]propan-2-ol
• 英文别名: 1-(2-Prop-1-en-2-ylphenyl)propan-2-ol
• CAS: 1259071-40-3
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: COQKOQGJXCDHAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-[2-(1-methylethenyl)phenyl]propan-2-ol 在 氢碘酸 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以55%的产率得到1,1,3-trimethylisochromane
  参考文献：
  名称：

  Synthesis of Isochromans by Hydriodic Acid or Iodine Mediated Cyclization Reactions of 1-(2-Vinylphenyl)propan-2-ols

  摘要：

  Treatment of 1-(2-vinylphenyl)propan-2-ols, which can be easily prepared from 2-bromostyrenes and epoxides, with hydriodic acid in acetonitrile yields the corresponding isochromans (1H-3,4-dihydro-2-benzopyrans). When the above alcohols are treated with iodine in acetonitrile in the presence of sodium hydrogencarbonate, the corresponding 1-iodomethylisochromans are obtained, which can be easily converted into the corresponding 1-alkyl(or aryl)sulfanylmethylisochromans on treatment with sodium thiolates in DMF.

  DOI：

  10.3987/com-10-12021
• 作为产物：
  描述：

  1-溴-2-丙-1-烯-2-基苯 、 methyloxirane 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 4.0h， 以59%的产率得到1-[2-(1-methylethenyl)phenyl]propan-2-ol
  参考文献：
  名称：

  Synthesis of Isochromans by Hydriodic Acid or Iodine Mediated Cyclization Reactions of 1-(2-Vinylphenyl)propan-2-ols

  摘要：

  Treatment of 1-(2-vinylphenyl)propan-2-ols, which can be easily prepared from 2-bromostyrenes and epoxides, with hydriodic acid in acetonitrile yields the corresponding isochromans (1H-3,4-dihydro-2-benzopyrans). When the above alcohols are treated with iodine in acetonitrile in the presence of sodium hydrogencarbonate, the corresponding 1-iodomethylisochromans are obtained, which can be easily converted into the corresponding 1-alkyl(or aryl)sulfanylmethylisochromans on treatment with sodium thiolates in DMF.

  DOI：

  10.3987/com-10-12021

文献信息

• Terminally unsaturated macromolecular monomers of polylactones and copolymers thereof
  申请人：THE B.F. GOODRICH COMPANY

  公开号：EP0291761A2

  公开（公告）日：1988-11-23

  Preparation of a macromolecular monomer of a lactone allows the preparation of copolymers of lactones with commonly available olefinically unsaturated monomers. There is no known method for the preparation of such copolymers. A cationic ring-opening polymerization of a lactone in conjunction with an unsaturated alcohol (propa­gator) having an acryloyl, allyl or styryl double bond, produces a polylactone macromer having an ethylenic double bond at one end and a hydroxyl group at the other. The polymerization proceeds by polyaddition of the lactone to the OH group which is the propagating species. The poly­lactone may include a polymeric or non-polymeric spacer. The propagator is a primary or secondary alcohol which, if cyclic may have a single internal double bond in one ring. The catalyst is an oxonium salt, or etherate of boron trifluoride. The macromer may be copolymerized with a wide variety of olefinically unsaturated monomers to form a macromer copolymer with pendant polylactone chains. In particular, block copolymers of terminally unsaturated macromers of ether-ester, or ester-ether structure may be tailored for specific applications.

  制备内酯大分子单体可以制备内酯与常见烯烃不饱和单体的共聚物。目前还没有制备这种共聚物的已知方法。内酯与具有丙烯酰基、烯丙基或苯乙烯酰基双键的不饱和醇（促进剂）进行阳离子开环聚合，可生成一端具有乙烯基双键、另一端具有羟基的聚内酯大分子。聚合反应是通过内酯与羟基的加成反应进行的，而羟基是聚合反应的传播物质。聚内酯可包括聚合物或非聚合物间隔物。繁殖体是伯醇或仲醇，如果是环状的，在一个环上可能有一个内部双键。催化剂为三氟化硼的羰基盐或醚化物。大色母粒可与多种烯烃不饱和单体共聚，形成具有下垂聚内酯链的大色母粒共聚物。特别是，醚-酯或酯-醚结构的末端不饱和大单体的嵌段共聚物可针对特定应用进行定制。
• JPS611632A
  申请人：——

  公开号：JPS611632A

  公开（公告）日：1986-01-07
• US4680358A
  申请人：——

  公开号：US4680358A

  公开（公告）日：1987-07-14
• US4791189A
  申请人：——

  公开号：US4791189A

  公开（公告）日：1988-12-13
• Synthesis of Isochromans by Hydriodic Acid or Iodine Mediated Cyclization Reactions of 1-(2-Vinylphenyl)propan-2-ols
  作者：Kazuhiro Kobayashi、Kazuaki Shikata、Hiroki Maegawa、Shuhei Fukamachi、Miyuki Tanmatsu、Hisatoshi Konishi

  DOI：10.3987/com-10-12021

  日期：——

  Treatment of 1-(2-vinylphenyl)propan-2-ols, which can be easily prepared from 2-bromostyrenes and epoxides, with hydriodic acid in acetonitrile yields the corresponding isochromans (1H-3,4-dihydro-2-benzopyrans). When the above alcohols are treated with iodine in acetonitrile in the presence of sodium hydrogencarbonate, the corresponding 1-iodomethylisochromans are obtained, which can be easily converted into the corresponding 1-alkyl(or aryl)sulfanylmethylisochromans on treatment with sodium thiolates in DMF.