ethyl 3-[(2S,3S)-2-azido-2-hydroxy-3-methylpyrrolidin-1-yl]benzoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: ethyl 3-[(2S,3S)-2-azido-2-hydroxy-3-methylpyrrolidin-1-yl]benzoate
• 化学式: C14H18N4O3
• 分子量: 290.32
• InChiKey: SXMUZAZGAKVZSF-IINYFYTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• m-SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING INTEGRIN ALPHA-V BETA-3 ANTAGONISM
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1229024A1

  公开（公告）日：2002-08-07

  An object of the present invention is to provide m-substituted benzoic acid derivatives having integrin αvβ3 antagonistic activity. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof, which are useful for the treatment or prevention of cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases, cancers and metastasis thereof, immunological diseases, osteopathy and other diseases: wherein A represents an optionally substituted heterocyclic group containing two nitrogen atoms, a bicylic group or the like; D represents a bond, >NR4, >CR5R6, O, S, or -NR4-CR5R6-; X represents CH or N; R7 and R8 represent hydroxyl, alkyl or the like; Q represents >C=O or the like; R9 represents hydrogen, alkyl or the like; J represents a bond or alkylene; R10 represents optionally substituted hydroxyl, amino or the like; R11 represents hydrogen, alkyl or the like; m is 0 to 5; n is 0 to 4; and p and q are each 0 to 3.

  本发明的目的是提供具有整合素αvβ3拮抗活性的m-取代苯甲酸衍生物。根据本发明的衍生物是由式(I)表示的化合物或其药学上可接受的盐或溶剂，可用于治疗或预防心血管疾病、血管生成相关疾病、脑血管疾病、癌症及其转移、免疫性疾病、骨病和其他疾病：其中A代表含有两个氮原子的可选择取代的杂环基团、双环基团或类似物；D代表键，>NR4，>CR5R6，O，S或-NR4-CR5R6-；X代表CH或N；R7和R8代表羟基、烷基或类似物；Q代表>C=O或类似物；R9代表氢、烷基或类似物；J代表键或烷基；R10代表可选择取代的羟基、氨基或类似物；R11代表氢、烷基或类似物；m为0至5；n为0至4；p和q各自为0至3。
• M-substituted benzoic acid derivatives having integrin alpha v beta 3 antagonistic activity
  申请人：Ajito Keiichi

  公开号：US20050059669A1

  公开（公告）日：2005-03-17

  An object of the present invention is to provide m-substituted benzoic acid derivatives having integrin α v β 3 antagonistic activity. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof, which are useful for the treatment or prevention of cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases, cancers and metastasis thereof, immunological diseases, osteopathy and other diseases: wherein A represents an optionally substituted heterocyclic group containing two nitrogen atoms, a bicylic group or the like; D represents a bond, >NR 4 , >CR 5 R 6 , O, S, or —NR 4 —CR 5 R 6 —; X represents CH or N; R 7 and R 8 represent hydroxyl, alkyl or the like; Q represents >C═O or the like; R 9 represents hydrogen, alkyl or the like; J represents a bond or alkylene; R 10 represents optionally substituted hydroxyl, amino or the like; R 11 represents hydrogen, alkyl or the like; m is 0 to 5; n is 0 to 4; and p and q are each 0 to 3.

  本发明的目的是提供具有整合素αvβ3拮抗活性的m-取代苯甲酸衍生物。根据本发明的衍生物是由式(I)表示的化合物或其药学上可接受的盐或溶剂，可用于治疗或预防心血管疾病、血管生成相关疾病、脑血管疾病、癌症及其转移、免疫性疾病、骨病和其他疾病：其中，A表示含有两个氮原子的可选择取代的杂环基团、双环基团或类似物；D表示键合、>NR4、>CR5R6、O、S或—NR4—CR5R6—；X表示CH或N；R7和R8表示羟基、烷基或类似物；Q表示>C═O或类似物；R9表示氢、烷基或类似物；J表示键合或烷基；R10表示可选择取代的羟基、氨基或类似物；R11表示氢、烷基或类似物；m为0至5；n为0至4；p和q各为0至3。