3-(1H-Indol-3-yl)-2-(4-methyl-benzoylamino)-propionic acid | 39545-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(1H-Indol-3-yl)-2-(4-methyl-benzoylamino)-propionic acid
• 英文别名: 3-(1H-indol-3-yl)-2-[(4-methylbenzoyl)amino]propanoic acid
• CAS: 39545-00-1
• 化学式: C₁₉H₁₈N₂O₃
• 分子量: 322.364
• InChiKey: BDSOKWRTLVKFSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• NOVEL COMPOUND HAVING ANTICANCER ACTIVITY, AND METHOD FOR PRODUCING SAME
  申请人：Medicinal Bioconvergence Research Center

  公开号：EP3939968A1

  公开（公告）日：2022-01-19

  The present invention pertains to a novel compound having anticancer activity, and a method for producing same, and more specifically, to a novel compound that exhibits excellent anticancer activity by inhibiting the expression of AIMP2-DX2, and a method for producing same. The compound represented by chemical formula 1 according to the present invention is highly effective in inhibiting the expression of AIMP2-DX2, and thus can be very advantageously used for the development of agents for treating various diseases, in particular cancer, caused by AIMP2-DX2.

  本发明涉及一种具有抗癌活性的新型化合物及其生产方法，更具体地说，涉及一种通过抑制 AIMP2-DX2 的表达而表现出优异抗癌活性的新型化合物及其生产方法。根据本发明的化学式 1 所代表的化合物在抑制 AIMP2-DX2 的表达方面非常有效，因此可以非常有利地用于开发治疗由 AIMP2-DX2 引起的各种疾病，特别是癌症的药物。
• [EN] TREATMENT FOR LIVER REGENERATION<br/>[FR] TRAITEMENT DE RÉGÉNÉRATION DU FOIE
  申请人：XENEXUS PHARMACEUTICALS PTY LTD

  公开号：WO2020014726A1

  公开（公告）日：2020-01-23

  Disclosed are pharmaceutical compositions comprising rebamipide together with one or more pharmaceutically acceptable carriers, diluents and excipients. Methods for use of the said compositions for increasing liver regeneration after partial hepatectomy and following liver transplantation to prevent postoperative liver failure and in the treatment of acute and chronic lilver failure are also disclosed.
• [EN] NOVEL COMPOUND HAVING ANTICANCER ACTIVITY, AND METHOD FOR PRODUCING SAME<br/>[FR] NOUVEAU COMPOSÉ AYANT UNE ACTIVITÉ ANTICANCÉREUSE, ET PROCÉDÉ DE PRODUCTION ASSOCIÉ<br/>[KO] 항암활성을 갖는 신규한 화합물 및 이의 제조방법
  申请人：MEDICINAL BIOCONVERGENCE RES CT

  公开号：WO2020204548A1

  公开（公告）日：2020-10-08

  본 발명은 항암활성을 갖는 신규한 화합물 및 이의 제조방법에 관한 것으로, 보다 상세하게는 AIMP2-DX2의 발현을 억제하여 우수한 항암활성을 나타내는 신규한 화합물 및 이의 제조방법에 관한 것이다. 본 발명에 따른 상기 화학식 1로 표시되는 화합물은 AIMP2-DX2의 발현을 저해하는 효과가 매우 우수하여, AIMP2-DX2에 의해 유발되는 다양한 질환들, 특히 암 치료제 개발에 매우 유용하게 활용될 수 있다.