3-[5-[(4-Tert-butylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[5-[(4-Tert-butylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
• 化学式: C₁₇H₁₉NO₃S₂
• 分子量: 349.5
• InChiKey: MYYCKVZMZUBXMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• THIOXOTHIAZOLIDINE INHIBITORS
  申请人：State of Colorado acting by and on behalf of the Board of Trustees of the University of Northern Co

  公开号：US20140004590A1

  公开（公告）日：2014-01-02

  The invention provides methods to inhibit the replication of a flavivirus, methods of inhibiting the guanosine triphosphate (GTP)-binding and guanylyltransferase activity of a flavivirus RNA capping enzyme, and methods of treating a subject infected with a flavivirus. The methods can include contacting a flavivirus with an effective amount of a thioxothiazolidine compound described herein, or a derivative thereof, such as a compound of Formula (I).
• US9206412B2
  申请人：——

  公开号：US9206412B2

  公开（公告）日：2015-12-08