7-(4-hydroxy-3-methoxy-5-nitrophenyl)-N-(2-methoxyphenyl)-5-methyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-(4-hydroxy-3-methoxy-5-nitrophenyl)-N-(2-methoxyphenyl)-5-methyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide
• 化学式: C20H19N7O6
• 分子量: 453.4
• InChiKey: HLCJFCHNLMPSTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  169
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Method of treating and/or preventing neurodegenerative diseases
  申请人：University of Macau

  公开号：US20160113931A1

  公开（公告）日：2016-04-28

  The present disclosure provides a method of treating and/or preventing neurodegenerative diseases, such as Parkinson disease, Alzheimer disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis, comprising administrating a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof to a subject in need thereof.