1-[[1-[3-(3,4-Dichlorophenoxy)-2-hydroxypropyl]piperidin-4-yl]amino]-3-(4-methoxyphenoxy)propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[[1-[3-(3,4-Dichlorophenoxy)-2-hydroxypropyl]piperidin-4-yl]amino]-3-(4-methoxyphenoxy)propan-2-ol
• 化学式: C₂₄H₃₂Cl₂N₂O₅
• 分子量: 499.4
• InChiKey: GLLVCRZCJVHXEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.4
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Modulators of cell adhesion, methods and compositions therefor
  申请人：Zonula Incorporated

  公开号：US20190100493A1

  公开（公告）日：2019-04-04

  Compounds with activity as modulators of cell adhesion are disclosed. The compounds are derivatives of piperidin-4-amine. In some embodiments, a compound can be linked to a targeting agent, a pharmaceutically active substance and/or a support material. Methods for enhancing or inhibiting classical cadherin-mediated functions are also disclosed. The compounds can be used for the treatment or prevention of a variety of diseases including cancer. Compositions and devices, including skin patches comprising a compound are also disclosed. In addition, methods of synthesis of the compounds are provided.

  揭示了作为细胞粘附调节剂的化合物。这些化合物是哌啶-4-胺的衍生物。在某些实施例中，化合物可以与靶向剂、药用活性物质和/或支持材料连接。还揭示了增强或抑制经典钙粘蛋白介导功能的方法。这些化合物可用于治疗或预防包括癌症在内的各种疾病。还揭示了包括含有化合物的皮肤贴片在内的组合物和器件。此外，还提供了化合物的合成方法。
• MODULATORS OF CELL ADHESION, METHODS AND COMPOSITIONS THEREFOR
  申请人：Blaschuk, Orest

  公开号：EP3692018A1

  公开（公告）日：2020-08-12
• [EN] MODULATORS OF CELL ADHESION, METHODS AND COMPOSITIONS THEREFOR<br/>[FR] MODULATEURS DE L'ADHÉSION CELLULAIRE, PROCÉDÉS ET COMPOSITIONS ASSOCIÉS
  申请人：BLASCHUK OREST

  公开号：WO2019070816A1

  公开（公告）日：2019-04-11

  Compounds with activity as modulators of cell adhesion are disclosed. The compounds are derivatives of piperidin-4-amine. In some embodiments, a compound can be linked to a targeting agent, a pharmaceutically active substance and/or a support material. Methods for enhancing or inhibiting classical cadherin-mediated functions are also disclosed. The compounds can be used for the treatment or prevention of a variety of diseases including cancer. Compositions and devices, including skin patches comprising a compound are also disclosed. In addition, methods of synthesis of the compounds are provided.