1-(3,4-Dichlorophenoxy)-3-[4-[[4-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-yl]propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,4-Dichlorophenoxy)-3-[4-[[4-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-yl]propan-2-ol
• 化学式: C₁₉H₂₁Cl₂F₃N₄O₂
• 分子量: 465.3
• InChiKey: DEXPLCIUOWIUDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Small molecule inhibitors of bacterial efflux pumps and methods of using same
  申请人：The Regents of the University of Colorado, a body Corporate

  公开号：US11110080B2

  公开（公告）日：2021-09-07

  An empirical Screen for Anti-infectives using Fluorescence microscopy of IntracellulaR Enterobacteriaceae (SAFIRE) was developed. Using this methodology, a library of small molecules and identified antimicrobials that are cell permeable and non-host-toxic were screened. Inhibitors of bacterial efflux pumps were identified as being implicated in antibiotic resistance and are attractive therapeutic targets for antimicrobials.

  利用荧光显微镜对细胞内肠杆菌科细菌进行抗感染药物经验筛选（SAFIRE）的方法已经开发出来。利用这种方法，筛选出了一个小分子库，并确定了可渗透细胞且无宿主毒性的抗菌剂。结果发现，细菌外排泵抑制剂与抗生素耐药性有关，是有吸引力的抗菌药物治疗靶点。
• SMALL MOLECULE INHIBITORS OF BACTERIAL EFFLUX PUMPS AND METHODS OF USING SAME
  申请人：The Regents of the University of Colorado, a body Corporate

  公开号：US20220175736A1

  公开（公告）日：2022-06-09

  An empirical Screen for Anti-infectives using Fluorescence microscopy of IntracellulaR Enterobacteriaceae (SAFIRE) was developed. Using this methodology, a library of small molecules and identified antimicrobials that are cell permeable and non-host-toxic were screened. Inhibitors of bacterial efflux pumps were identified as being implicated in antibiotic resistance and are attractive therapeutic targets for antimicrobials.