1-[4-[3-(9H-fluoren-9-yl)-2-hydroxypropyl]piperazin-1-yl]-3-(1,3,6-tribromo-9H-fluoren-9-yl)propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-[3-(9H-fluoren-9-yl)-2-hydroxypropyl]piperazin-1-yl]-3-(1,3,6-tribromo-9H-fluoren-9-yl)propan-2-ol
• 化学式: C₃₆H₃₅Br₃N₂O₂
• 分子量: 767.4
• InChiKey: NFKZAYGAZSLISU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] 1, 4- SUBSTITUTED PIPERIDINE DERIVATIVES AND USE THEREOF AS BASE-INHIBITORS IN TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] DERIVES DE PIPERIDINE 1, 4-SUBSTITUES ET LEUR UTILISATION COMME INHIBITEURS DES BASES DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：NOVO PHARMACEUTICALS LTD DE

  公开号：WO2004020422A1

  公开（公告）日：2004-03-11

  A compound of formula, (I) wherein R1 and R2 are the same or different and are each cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, polycyclyl or heteropolycyclyl; R3 and R4 are the same or different and are each hydrogen, alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl or polycyclyl; X and Y are the same or different and are each a bond, alkylene, alkenylene, -O-alkyl- or -O-alkenyl-; and m and n are the same or different and are each 0 or 1;or a pharmaceutically-acceptable salt thereof.