Bis(4-nitrophenyl) pentanedioate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: Bis(4-nitrophenyl) pentanedioate
• 化学式: C17H14N2O8
• 分子量: 374.3
• InChiKey: IOIJXIHQQRSQDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  144
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-hydrazinophthalazine 、 Bis(4-nitrophenyl) pentanedioate 以97%的产率得到
  参考文献：
  名称：

  ZIMMER H.; KOKOSA J. M.; SHAH K. J., J. ORG. CHEM. , 1975, 40, NO 20, 2901-2906

  摘要：

  DOI：

文献信息

• EP0697906A4
  申请人：——

  公开号：EP0697906A4

  公开（公告）日：1996-07-17
• ARTIFICIAL RECEPTORS, ANTIBODIES, AND ENZYMES
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：EP0697906A1

  公开（公告）日：1996-02-28
• BIODEGRADABLE WATER SOLUBLE POLYMERS
  申请人：Medivas, LLC

  公开号：EP2021141A2

  公开（公告）日：2009-02-11
• Biodegradable water soluble polymers
  申请人：Gomurashvili D. Zaza

  公开号：US20070282011A1

  公开（公告）日：2007-12-06

  The invention provides biodegradable, water soluble PEA, PEUR and PEU carrier polymers, which can be used to conjugate, and thereby stabilize and/or solubilize, bioactive agents via polar uncharged or charged groups and activated ester or amino groups contained in the building blocks that make up the backbone of the polymer. The bioactive agents are released at a controlled rate determined by biodegradation of the polymers. The highly versatile Active Polycondensation (APC) method, which is mainly carried out in solution at mild temperatures, readily allows synthesis of such polymers. The invention water soluble polymers can also be used as water solubilizing tethers to attach drugs, and biologics to the surface of such carrier constructs as liposomes, particles and micelles.
• SYNTHETIC IMMUNOGENIC GLYCOCONJUGATE FOR MELANOMA IMMUNOTHERAPY
  申请人：Nativi Cristina

  公开号：US20120263735A1

  公开（公告）日：2012-10-18

  The present invention refers to compounds of formula (I) as useful melanoma vaccines' active ingredients. As a matter of fact, compounds of formula (I) are immunogenic artificial antigens, mimetics of GM3 and GM3 lactone, well known tumor associated antigens (TAAs). In addition, the present invention refers to specific antibodies for compounds of formula (I) which are able to bind to the TAAs. The hereinabove reported compounds and antibodies are therefore potentially useful respectively for the active and passive immunization against tumors overexpressing GM3 ganglioside, in a preferred embodiment melanoma and colon cancer, and for their diagnosis and prognosis.