3-[(2-nitrophenyl)sulfanylmethyl]-4-prop-2-enyl-1H-1,2,4-triazole-5-thione | 675104-49-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(2-nitrophenyl)sulfanylmethyl]-4-prop-2-enyl-1H-1,2,4-triazole-5-thione
• CAS: 675104-49-1
• 化学式: C12H12N4O2S2
• 分子量: 308.4
• InChiKey: VWFIHGWHMXSTAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  131
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Suppression of Sars Replication by Sars Helicase Inhibitors
  申请人：The Curators of the University of Missouri

  公开号：US20140005241A1

  公开（公告）日：2014-01-02

  The present invention relates to compounds, compositions, and methods, for treating subjects suspected of needing treatment for a Nidovirales virus infection. In certain embodiments, the compounds comprise Nidovirales helicase inhibitors that do not significantly affect helicase ATPase enzymatic activity or nucleic acid binding activity of the helicase.
• US9266844B2
  申请人：——

  公开号：US9266844B2

  公开（公告）日：2016-02-23
• [EN] SUPPRESSION OF SARS REPLICATION BY SARS HELICASE INHIBITORS<br/>[FR] SUPPRESSION DE LA RÉPLICATION DU SRAS PAR DES INHIBITEURS DE L'HÉLICASE DU SRAS
  申请人：UNIV MISSOURI

  公开号：WO2013188887A1

  公开（公告）日：2013-12-19

  The present invention relates to compounds, compositions, and methods, for treating subjects suspected of needing treatment for a Nidovirales virus infection. In certain embodiments, the compounds comprise Nidovirales helicase inhibitors that do not significantly affect helicase ATPase enzymatic activity or nucleic acid binding activity of the helicase.